Reappraisal of the Relationship between the HIV-1-Protective Single-Nucleotide Polymorphism 35 Kilobases Upstream of the HLA-C Gene and Surface HLA-C Expression

被引：46

作者：

Corrah, Tumena W. ^{[1
]}

Goonetilleke, Nilu ^{[1
]}

Kopycinski, Jakub ^{[2
]}

Deeks, Steven G. ^{[3
]}

Cohen, Myron S. ^{[4
]}

Borrow, Persephone ^{[5
]}

McMichael, Andrew ^{[1
]}

Brackenridge, Simon ^{[1
]}

机构：

[1] Univ Oxford, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[2] Univ London Imperial Coll Sci Technol & Med, IAVI Human Immunol Lab, London, England

[3] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[4] Univ N Carolina, Sch Med, Dept Med, Chapel Hill, NC USA

[5] Univ Oxford, Nuffield Dept Clin Med, Oxford OX3 9DS, England

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 07期

基金：

英国惠康基金;

关键词：

CLASS-I MOLECULES; SEQUENCE-DERIVED PEPTIDES; NATURAL-KILLER-CELLS; HIV-1; INFECTION; VIRAL LOAD; MONOCLONAL-ANTIBODIES; MAJOR DETERMINANTS; VIRUS-REPLICATION; IMMUNE CONTROL; HOST CONTROL;

D O I：

10.1128/JVI.02276-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Previous studies have found an association between a single-nucleotide polymorphism 35 kb upstream of the HLA-C locus (-35 SNP), HLA-C expression, and HIV-1 set point viral loads. We show that the difference in HLA-C expression across -35 SNP genotypes can be attributed primarily to the very low expression of a single allelic product, HLA-Cw7, which is a common HLA type. We suggest that association of the -35 SNP and HIV-1 load manifests as a result of linkage disequilibrium of this polymorphism with both favorable and unfavorable HLA-C and -B alleles.

引用

页码：3367 / 3374

页数：8

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