Do nonsteroidal anti-inflammatory drugs affect the risk of developing ovarian cancer? A meta-analysis

被引:46
作者
Bonovas, S
Filioussi, K
Sitaras, NM
机构
[1] Univ Athens, Sch Med, Dept Pharmacol, GR-10679 Athens, Greece
[2] HCIDC, Dept Epidemiol Surveillance & Intervent, Athens, Greece
关键词
aspirin; epidemiology; meta-analysis; nonsteroidal anti-inflammatory drugs; ovarian cancer;
D O I
10.1111/j.1365-2125.2005.02386.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Aim The relationship between the use of nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, and the risk of ovarian cancer has been controversial. This study examines the strength of this association by conducting a detailed meta-analysis of the studies published in peer-reviewed literature on the subject. Methods A comprehensive search for articles published up to April 2004 was performed, reviews of each study were conducted and data were abstracted. Prior to meta-analysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk estimates (RR) and 95% confidence intervals (CIs) were calculated. Results Ten reports (six case-control and four cohort studies), published between 1998 and 2004, were identified. There was no evidence of an association between aspirin use and ovarian cancer risk either assuming a random-effects model (RR = 0.92, 95% CI 0.80, 1.06), or a fixed-effects model (RR = 0.93, 95% CI 0.81, 1.06). Similarly, we did not find evidence of an association between non-aspirin NSAID use and ovarian cancer, both on the basis of a random-effects model (RR = 0.86, 95% CI 0.68, 1.08), and on the basis of a fixed-effects model (RR = 0.88, 95% CI 0.76, 1.01). When the analyses were stratified into subgroups, there was no evidence that study design substantially influenced the estimate of effects. Furthermore, our analysis did not show decreasing risks with increasing frequency or duration of use, features often associated with causal relationships. Conclusions Our meta-analysis findings do not support that NSAID use plays a role in the chemoprevention of ovarian cancer. Future research should examine potential relationships between specific NSAIDs and ovarian cancer, taking into account the possible biases that may have affected this meta-analysis.
引用
收藏
页码:194 / 203
页数:10
相关论文
共 56 条
[1]   Aspirin and epithelial ovarian cancer [J].
Akhmedkhanov, A ;
Toniolo, P ;
Zeleniuch-Jacquotte, A ;
Kato, I ;
Koenig, KL ;
Shore, RE .
PREVENTIVE MEDICINE, 2001, 33 (06) :682-687
[2]  
[Anonymous], 1995, JAMA, V273, P491
[3]  
[Anonymous], CANC FACTS FIG 2004
[4]  
[Anonymous], METAANALYSIS DECISIO
[5]  
Baron JA, 2003, PROG EXP TUMOR RES, V37, P1
[6]   OPERATING CHARACTERISTICS OF A BANK CORRELATION TEST FOR PUBLICATION BIAS [J].
BEGG, CB ;
MAZUMDAR, M .
BIOMETRICS, 1994, 50 (04) :1088-1101
[7]   Aspirin and cancer risk: an update to 2001 [J].
Bosetti, C ;
Gallus, S ;
La Vecchia, C .
EUROPEAN JOURNAL OF CANCER PREVENTION, 2002, 11 (06) :535-542
[8]  
CASAGRANDE JT, 1979, LANCET, V2, P170
[9]   Rheumatoid arthritis and the risk of malignancy [J].
Cibere, J ;
Sibley, J ;
Haga, M .
ARTHRITIS AND RHEUMATISM, 1997, 40 (09) :1580-1586
[10]   THE COMBINATION OF ESTIMATES FROM DIFFERENT EXPERIMENTS [J].
COCHRAN, WG .
BIOMETRICS, 1954, 10 (01) :101-129