Microinjections of nociceptin into the nucleus ambiguus elicit tachycardia in the rat

被引：8

作者：

Chitravanshi, VC ^{[1
]}

Sapru, HN ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Neurol Surg, Newark, NJ 07103 USA

来源：

BRAIN RESEARCH | 2005年 / 1051卷 / 1-2期

关键词：

glutamate; heart rate; ORL1; receptor;

D O I：

10.1016/j.brainres.2005.06.023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cardiovascular effects of activation of opioid receptor like receptors (ORL1 receptors) in the nucleus ambiguus were studied in urethane-anesthetized, adult male Wistar rats. Microinjections of nociceptin (0.31, 0.62, 1.25 and 2.25 mmol/L) into the nucleus ambiguus elicited increases in heart rate (17.5 +/- 4, 33.3 +/- 2.9, 16.5 +/- 1.5 and 13.9 +/- 2.7 beats/min, respectively) which were blocked by an ORL1 receptor antagonist. These results indicate that activation of ORL1 receptors in the nucleus ambiguus elicits tachycardia. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：199 / 204

页数：6

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