Polymorphism and desolvation of flupirtine maleate

被引：13

作者：

Landgraf, KF ^{[1
]}

Olbrich, A ^{[1
]}

Pauluhn, S ^{[1
]}

Emig, P ^{[1
]}

Kutscher, B ^{[1
]}

Stange, H ^{[1
]}

机构：

[1] ASTA Med AG, Dresden, Germany

来源：

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 1998年 / 46卷 / 03期

关键词：

flupirtine maleate; polymorphism; modification; desolvation; X-ray diffractometry; polarization microscopy; thermoanalysis;

D O I：

10.1016/S0939-6411(98)00054-X

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Crystallizates of the analgesic agent flupirtine maleate (Katadolon(R); ASTA Medica, Dresden, Germany) obtained from isopropanol are examined by X-ray diffractometry, polarization microscopy and thermoanalysis. Depending on the crystallizing conditions, the modifications A and B as well as an isopropanol solvate are observed. The inversion temperature A --> B of the enantiotropic modifications is 164 degrees C (differential scanning calorimetry (DSC) onset). During thermal desolvation, modification B is formed well below the inversion temperature. In concentrated isopropanol suspensions, the solvate and modification B are rapidly transformed into modification A. It is shown bow phase-pure products consisting of modification A, which is better wettable with water and stable at room temperature, can be obtained. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：329 / 337

页数：9