Two domains of the Borna disease virus p40 protein are required for interaction with the p23 protein

被引：26

作者：

Berg, M

Ehrenborg, C

Blomberg, J

Pipkorn, R

Berg, AL

机构：

[1] Swedish Univ Agr Sci, Dept Vet Microbiol, Immunol Sect, S-75123 Uppsala, Sweden

[2] Swedish Univ Agr Sci, Dept Pathol, S-75123 Uppsala, Sweden

[3] Uppsala Grad Sch Biomed Res, Uppsala, Sweden

[4] Uppsala Univ, Acad Hosp, Dept Clin Microbiol, Sect Virol, Uppsala, Sweden

[5] Deutsch Krebsforschungszentrum, D-6900 Heidelberg, Germany

来源：

JOURNAL OF GENERAL VIROLOGY | 1998年 / 79卷

关键词：

D O I：

10.1099/0022-1317-79-12-2957

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Borna disease virus (BDV) has five major open reading frames, which encode the proteins p40, p23, gp18, p57 and p190, By analogy with other negative-strand RNA viruses, p40 is a putative nucleoprotein and p23 is a putative phosphoprotein. These proteins are known to form complexes with each other and with the polymerase protein in other viruses. In this paper, it is shown that BDV p40 and p23 can form complexes with each other in infected cells. Furthermore, the amino acids of p40 that are necessary for formation of this complex have been mapped.

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页码：2957 / 2963

页数：7

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