The 14-3-3 cancer connection

被引：363

作者：

Hermeking, H ^{[1
]}

机构：

[1] Max Planck Inst Biochem, D-82152 Martinsried, Germany

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 12期

关键词：

D O I：

10.1038/nrc1230

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

14-3-3 proteins regulate many cellular processes that are important in cancer biology, such as apoptosis and cell-cycle checkpoints. There are seven human 14-3-3 genes and one of these, 14-3-3sigma, has been directly implicated in the aetiology of human cancer. Loss of 14-3-3sigma expression sensitizes cancer cells to conventional anticancer agents, so its inhibition could be exploited for therapeutic purposes. Interference with 14-3-3 function as a therapeutic approach is being evaluated at present and, in the case of UCN-01, is under clinical investigation.

引用

页码：931 / 943

页数：13

共 141 条

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