Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy

被引：34

作者：

Nishimura, M ^{[1
]}

Kuno, S

Kaji, R

Kawakami, H

机构：

[1] Konan Hosp, Clin Res Ctr, Shiga 5202433, Japan

[2] Musashi Hosp, Natl Ctr Neurol & Psychiat, Kodaira, Tokyo, Japan

[3] Univ Tokushima, Dept Neurol, Sch Med, Tokushima 770, Japan

[4] Hiroshima Univ, Grad Sch Biomed Sci, Dept Clin Neurosci & Therapeut, Hiroshima, Japan

来源：

MOVEMENT DISORDERS | 2005年 / 20卷 / 08期

关键词：

Alzheimer's disease; multiple system atrophy; Parkinson's disease; brain-derived neurotrophic factor; polymorphism;

D O I：

10.1002/mds.20491

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We studied two genetic polymorphisms (240C/T and 480G/A) of the brain-derived neurotrophic factor (BDNF) gene in Japanese patients with Alzheimer's disease (AD, n = 172), Parkinson's disease (PD, n = 327), and multiple system atrophy (MSA, n = 122), as well as controls (n = 275). The distribution of the 240 C/T polymorphism was significantly different between AD patients and controls, whereas there was no difference in the genotype of the two polymorphisms between MSA and controls or between PD and controls. Our data suggest that BDNF might play a role in AD. (c) 2005 Movement Disorder Society.

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收藏

页码：1031 / 1033

页数：3

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