Tissue factor in patients with acute coronary syndromes - Expression in platelets, leukocytes, and platelet-leukocyte aggregates

被引：98

作者：

Brambilla, Marta ^{[1
]}

Camera, Marina ^{[1
,2
]}

Colnago, Deborah ^{[2
]}

Marenzi, Giancarlo ^{[2
]}

De Metrio, Monica ^{[2
]}

Giesen, Peter L. ^{[4
]}

Balduini, Alessandra ^{[3
]}

Veglia, Fabrizio ^{[2
]}

Gertow, Karl ^{[2
]}

Biglioli, Paolo ^{[2
]}

Tremoli, Elena ^{[1
,2
]}

机构：

[1] Univ Milan, Dept Pharmacol Sci, I-20133 Milan, Italy

[2] Ctr Cardiol Monzino IRCCS, Milan, Italy

[3] Univ Pavia, Dept Biochem, I-27100 Pavia, Italy

[4] Thrombinoscope CV, Maastricht, Netherlands

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2008年 / 28卷 / 05期

关键词：

platelet-leukocyte aggregates; tissue factor; acute coronary syndrome; thrombosis;

D O I：

10.1161/ATVBAHA.107.161471

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective-Activated platelets and circulating platelet-leukocyte aggregates (PLA) are significantly higher in patients with unstable angina than in those with stable angina (SA). Platelets from healthy subjects express TF on activation. The aim of this study was to investigate the expression of TF in PLA, in platelets, and in monocytes of acute coronary syndrome (ACS) patients compared to SA patients and healthy subjects (Controls). Methods and Results-We enrolled 26 consecutive patients with ACS, 29 patients with SA, and 25 Controls. A significantly greater number of total and TF positive platelet-monocyte aggregates was found by flow cytometry in blood of ACS patients than in either SA patients (3-fold) or Controls (5-fold). ACS patients also had a significantly higher amount of TF-positive platelets than SA or Controls (> 3-fold) and significantly higher thrombin generation capacity. TF mRNA expression in platelets was significantly higher in ACS patients than in SA or Controls. Conclusions-In ACS patients the greater expression of TF in platelets and PLA strengthens the link between platelet activation, blood coagulation, and thrombus formation and may further contribute to the hypercoagulability associated with the disease.

引用

页码：947 / 953

页数：7

共 36 条

[1] The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques [J].