Brief report Initial bone marrow reticulin fibrosis in polycythemia vera exerts an impact on clinical outcome

被引：90

作者：

Barbui, Tiziano ^{[1
]}

Thiele, Juergen ^{[2
]}

Passamonti, Francesco ^{[3
]}

Rumi, Elisa ^{[4
]}

Boveri, Emanuela ^{[4
]}

Randi, Maria Luigia ^{[5
]}

Bertozzi, Irene ^{[5
]}

Marino, Filippo ^{[5
]}

Vannucchi, Alessandro M. ^{[6
]}

Pieri, Lisa ^{[6
]}

Rotunno, Giada ^{[6
]}

Gisslinger, Heinz

Gisslinger, Bettina

Muellauer, Leonhard ^{[7
]}

Finazzi, Guido ^{[1
]}

Carobbio, Alessandra ^{[1
]}

Gianatti, Andrea ^{[1
]}

Ruggeri, Marco ^{[8
]}

Nichele, Ilaria ^{[8
]}

D'Amore, Emanuele ^{[8
]}

Rambaldi, Alessandro ^{[1
]}

Tefferi, Ayalew ^{[9
]}

机构：

[1] Osped Riuniti Bergamo, I-24128 Bergamo, Italy

[2] Univ Cologne, D-50931 Cologne, Germany

[3] Osped Varese, Varese, Italy

[4] Univ Pavia, Policlin San Matteo, Fdn Ist Ricovero & Cura Carattere Sci, I-27100 Pavia, Italy

[5] Univ Padua, Padua, Italy

[6] Univ Florence, Florence, Italy

[7] Med Univ Vienna, Inst Pathol, Vienna, Austria

[8] San Bortolo Hosp, Vicenza, Italy

[9] Mayo Clin, Rochester, MN USA

来源：

BLOOD | 2012年 / 119卷 / 10期

关键词：

CHRONIC MYELOPROLIFERATIVE DISORDERS; ESSENTIAL THROMBOCYTHEMIA; HISTOPATHOLOGY; MYELOFIBROSIS;

D O I：

10.1182/blood-2011-11-393819

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization-defined polycythemia vera evaluated at the time of initial diagnosis. Seventy-four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-grade fibrosis. Presenting clinical and laboratory characteristics, including JAK2V617F allele burden, between patients with and without fibrosis were similar for the most part, with the exception of a higher prevalence of palpable splenomegaly in patients with fibrosis (P < .01). Patients with fibrosis were less prone to experience thrombosis during their clinical course (1.1 vs 2.7 per 100 patient-years; P = .03) and more prone to develop post-polycythemia vera myelofibrosis (2.2 vs 0.8 per 100 patient-years; P = .01). There was no significant difference between the 2 groups in terms of overall or leukemia-free survival. The present study clarifies the incidence, degree, and prognostic relevance of bone marrow fibrosis obtained at time of initial diagnosis of polycythemia vera. (Blood. 2012;119(10):2239-2241)

引用

页码：2239 / 2241

页数：3

共 15 条

[1] The impact of peripheral blood values and bone marrow findings on prognosis for patients with essential thrombocythemia and polycythemia vera [J].