Methylenetetrahydrofolate reductase polymorphisms, C677T and A1298C, are associated with methotrexate-related toxicities in Korean patients with rheumatoid arthritis

被引：25

作者：

Choe, Jung-Yoon ^{[1
]}

Lee, Hwajeong ^{[1
]}

Jung, Hyun-Young ^{[1
]}

Park, Sung-Hoon ^{[1
]}

Bae, Sang-Cheol ^{[2
]}

Kim, Seong-Kyu ^{[1
]}

机构：

[1] Catholic Univ Daegu, Sch Med, Arthrit & Autoimmun Res Ctr, Dept Internal Med, Taegu 705718, South Korea

[2] Hanyang Univ, Coll Med, Hosp Rheumat Dis, Dept Rheumatol, Seoul 133791, South Korea

来源：

RHEUMATOLOGY INTERNATIONAL | 2012年 / 32卷 / 06期

关键词：

Methotrexate; Methylenetetrahydrofolate reductase; Polymorphism; Toxicity; Rheumatoid arthritis; SINGLE-NUCLEOTIDE POLYMORPHISMS; GENETIC RISK-FACTOR; THERAPY; MTHFR; EFFICACY; MUTATION; DISEASE; ENZYMES; UPDATE;

D O I：

10.1007/s00296-011-1989-5

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

We investigated associations between the methylenetetrahydrofolate reductase (MTHFR) polymorphisms C677T and A1298C and methotrexate (MTX)-related toxicities in Korean patients with rheumatoid arthritis (RA) taking MTX. One hundred sixty-seven patients with RA were enrolled in a cross-sectional study and genotyped for the single-nucleotide polymorphisms C677T and A1298C in MTHFR. Alleles, genotypes, and haplotypes of the C677T and A1298C polymorphisms were not associated with specific MTX toxicities. However, among RA patients with the 1298CC genotype, the proportion who experienced at least one toxicity was significantly greater than the proportion of patients with 1298AA who did (P = 0.043). In addition, the proportion of patients with the 677C/1298A haplotype who experienced toxicity was greater than the proportion of those with 677C/1298C who did (P = 0.032, odds ratio = 2.085, 95% confidence interval 1.058-4.106). In this study, MTHFR polymorphisms were associated with MTX toxicities in Korean patients with RA. Further study for association of MTHFR polymorphisms with MTX toxicities should be needed in larger RA population.

引用

页码：1837 / 1842

页数：6

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