Vertically aligned multiwall-carbon nanotubes to preferentially entrap highly metastatic cancerous cells

被引：30

作者：

Abdolahad, M. ^{[1
]}

Sanaee, Z. ^{[1
]}

Janmaleki, M. ^{[2
]}

Mohajerzadeh, S. ^{[1
]}

Abdollahi, M. ^{[3
]}

Mehran, M. ^{[1
]}

机构：

[1] Univ Tehran, Sch Elect & Comp Eng, Thin Film & Nanoelect Lab, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Taleghani Hosp, Nanomed & Tissue Engn Res Ctr, Tehran, Iran

[3] Iranian Soc Pathol, Tehran, Iran

来源：

CARBON | 2012年 / 50卷 / 05期

关键词：

ATOMIC-FORCE MICROSCOPY; FLOW-CYTOMETRY; LIVING CELLS; ELASTICITY; DEFORMABILITY; TRANSPORTERS; COMPRESSION; FIBROBLASTS; ASPIRATION; DELIVERY;

D O I：

10.1016/j.carbon.2012.01.001

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

We have investigated the entrapment of colon cancer cells with two different metastatic grades on arrays of multiwall carbon nanotubes. It has been observed that the fraction of entrapment of higher metastatic cancer cells is significantly more than lower metastatic grades. The observed effects are due to the more deformability and softness of higher metastatic malignant cells in comparison with the lower ones both for live and fixed cells. Also cell fixation results in a decrease of their entrapment due to an increase in cell rigidity by the fixation process. The present phenomenon describes a new application of vertically aligned carbon nanotubes to distinguish the healthy and cancerous cells by means of their different deformability properties during entrapment on such arrays. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2010 / 2017

页数：8

共 42 条

[1]

Embedded vertically grown carbon nanotubes for field emission applications [J].

Abdi, Yaser ;

Koohshorkhi, Javad ;

Mohajerzadeh, Shams ;

Darbari, Sara ;

Sanaee, Zeinab .

JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B, 2007, 25 (03) :822-828

[2]

Adami OA, 2002, TXB CANC EPIDEMIOLOG

[3]

Silver nanoparticles within vertically aligned multi-wall carbon nanotubes with open tips for antibacterial purposes [J].

Akhavan, O. ;

Abdolahad, M. ;

Abdi, Y. ;

Mohajerzadeh, S. .

JOURNAL OF MATERIALS CHEMISTRY, 2011, 21 (02) :387-393

[4]

Synthesis of titania/carbon nanotube heterojunction arrays for photoinactivation of E. coli in visible light irradiation [J].

Akhavan, O. ;

Abdolahad, M. ;

Abdi, Y. ;

Mohajerzadeh, S. .

CARBON, 2009, 47 (14) :3280-3287

[5]

ALBERTS B, 2008, MOL BIOL CEL

[6]

Microfluidic electroporative flow cytometry for studying single-cell biomechanics [J].

Bao, Ning ;

Zhan, Yihong ;

Lu, Chang .

ANALYTICAL CHEMISTRY, 2008, 80 (20) :7714-7719

[7]

Ben ZA, 1985, BIOCHIM BIOPHYS ACTA, V780, P197

[8]

Contribution of the nucleus to the mechanical properties of endothelial cells [J].

Caille, N ;

Thoumine, O ;

Tardy, Y ;

Meister, JJ .

JOURNAL OF BIOMECHANICS, 2002, 35 (02) :177-187

[9]

Elasticity measurement of living cells with an atomic force microscope: data acquisition and processing [J].

Carl, Philippe ;

Schillers, Hermann .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2008, 457 (02) :551-559

[10]

Nanomechanical analysis of cells from cancer patients [J].

Cross, Sarah E. ;

Jin, Yu-Sheng ;

Rao, Jianyu ;

Gimzewski, James K. .

NATURE NANOTECHNOLOGY, 2007, 2 (12) :780-783

← 1 2 3 4 5 →