ROR1 is expressed on hematogones (non-neoplastic human B-lymphocyte precursors) and a minority of precursor-B acute lymphoblastic leukemia

被引：74

作者：

Broome, H. Elizabeth ^{[1
]}

Rassenti, Laura Z. ^{[2
]}

Wang, Huan-You ^{[1
]}

Meyer, Lilly M. ^{[1
]}

Kipps, Thomas J. ^{[2
]}

机构：

[1] Univ Calif San Diego, Dept Pathol, Moores Canc Ctr, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Med, Moores Canc Ctr, La Jolla, CA 92093 USA

来源：

LEUKEMIA RESEARCH | 2011年 / 35卷 / 10期

关键词：

ROR1; Wnt; B-lymphocyte precursors; Hematogones; Acute lymphoblastic leukemia; t(1; 19); Chronic lymphocytic leukemia; Flow cytometry; RECEPTOR TYROSINE KINASE; BONE-MARROW; CELL PRECURSORS; TARGET;

D O I：

10.1016/j.leukres.2011.06.021

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

ROR1 is a receptor tyrosine kinase expressed during embryogenesis, on chronic lymphocytic leukemia (CLL) and in other malignancies. Hematogones (non-neoplastic B-lymphocyte precursors) express surface ROR1 at an intermediate stage of maturation that lacks CD34 or TdT. The neoplastic counterpart to hematogones is precursor-B acute lymphoblastic leukemia (B-ALL), but less than 10% of B-ALL express surface ROR1, and these ROR1+ B-ALL cases have an unusually high frequency of lacking CD34 and/or having t(1; 19), a chromosomal translocation that defines a specific subtype of B-ALL. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1390 / 1394

页数：5

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