In vitro activities of doripenem and comparator agents against 364 anaerobic clinical isolates

被引：38

作者：

Wexler, HM

Engel, AE

Glass, D

Li, CD

机构：

[1] Greater Los Angeles Vet Adm Hlth Care Serv, Med & Res Serv, Los Angeles, CA USA

[2] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 10期

关键词：

D O I：

10.1128/AAC.49.10.4413-4417.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activities of doripenem against 364 anaerobic isolates were measured and compared to those of ertapenem, imipenem, meropenem, ceftriaxone, and levotloxacin. All of the carbapenems were active against nearly all Bacteroides fragilis group isolates. Doripenem was either comparable to or slightly less active than imipenem and meropenem against most isolates but more active than the other penems against Clostridium difficile. Doripenem appears to have excellent activity against a broad range of anaerobes.

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页码：4413 / 4417

页数：5

相关论文

共 20 条

[1] SUSCEPTIBILITY PATTERNS AND RESISTANCE TO IMIPENEM IN THE BACTEROIDES-FRAGILIS GROUP SPECIES IN JAPAN - A 4-YEAR STUDY [J].

BANDOH, K ;

UENO, K ;

WATANABE, K ;

KATO, N .

CLINICAL INFECTIOUS DISEASES, 1993, 16 :S382-S386

[2] Expression of the carbapenemase gene (cfiA) in Bacteroides fragilis [J].

Edwards, R ;

Read, PN .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (06) :1009-1012

[3] Relationship between outer membrane protein profiles and resistance to ceftazidime, imipenem, and ciprofloxacin in Pseudomonas aeruginosa isolates from bacteremic patients [J].

Gimeno, C ;

Navarro, D ;

Savall, F ;

Millas, E ;

Farga, MA ;

Garau, J ;

Cisterna, R ;

GarciaDeLomas, J .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1996, 15 (01) :82-85

[4] Comparative in vitro activities of ertapenem (MK-0826) against 1,001 anaerobes isolated from human intra-abdominal infections [J].

Goldstein, EJC ;

Citron, DM ;

Merriam, CV ;

Warren, Y ;

Tyrrell, KL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (09) :2389-2394

[5]

JOUSIMIESSOMER H, 2002, WADSWORTH KTL ANEARO

[6] In vitro and in vivo antibacterial activities of a new injectable carbapenem, S-4661, against gynaecological pathogens [J].

Mikamo, H ;

Izumi, K ;

Hua, YX ;

Hayasaki, Y ;

Sato, Y ;

Tamaya, T .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 46 (03) :471-474

[7] Comparative stability of carbapenem and penem antibiotics to human recombinant dehydropeptidase-I [J].

Mori, M ;

Hikida, M ;

Nishihara, T ;

Nasu, T ;

Misuhashi, S .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 37 (05) :1034-1036

[8]

*NAT COMM CLIN LAB, 2003, M11A6 NCCLS

[9] In vitro antibacterial activity of S-4661, a new parenteral carbapenem, against urological pathogens isolated from patients with complicated urinary tract infections [J].

Nomura, S ;

Nagayama, A .

JOURNAL OF CHEMOTHERAPY, 2002, 14 (02) :155-160

[10] Role of putative loops 2 and 3 in imipenem passage through the specific porin OprD of Pseudomonas aeruginosa [J].

Ochs, MM ;

Bains, M ;

Hancock, REW .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (07) :1983-1985