In vivo selection of Klebsiella pneumoniae strains with enhanced quinolone resistance during fluoroquinolone treatment of urinary tract infections

被引：41

作者：

Deguchi, T

Kawamura, T

Yasuda, M

Nakano, M

Fukuda, H

Kato, H

Kato, N

Okano, Y

Kawada, Y

机构：

[1] GIFU UNIV,SCH MED,DEPT MOL PATHOBIOCHEM,GIFU 500,JAPAN

[2] GIFU UNIV,SCH MED,INST ANAEROB BACTERIOL,GIFU 500,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 07期

关键词：

D O I：

10.1128/AAC.41.7.1609

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We report two cases of failure of fluoroquinolone treatment of urinary tract infections with Klebsiella pneumoniae strains harboring quinolone resistance-associated alterations in GyrA and ParC and in vivo selection of posttreatment isolates with enhanced fluoroquinolone resistance. Active efflux leading to decreased accumulation of a drug enhanced fluoroquinolone resistance in one posttreatment isolate, and an additional mutation in parC resulting in an additional amino acid change in ParC was associated with increased resistance in the other.

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页码：1609 / 1611

页数：3

相关论文

共 16 条

[1] Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV [J].

Breines, DM ;

Ouabdesselam, S ;

Ng, EY ;

Tankovic, J ;

Shah, S ;

Soussy, CJ ;

Hooper, DC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (01) :175-179

[2] Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae [J].

Deguchi, T ;

Fukuoka, A ;

Yasuda, M ;

Nakano, M ;

Ozeki, S ;

Kanematsu, E ;

Nishino, Y ;

Ishihara, S ;

Ban, Y ;

Kawada, Y .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (03) :699-701

[3] CROSS-RESISTANCE TO NALIDIXIC-ACID, TRIMETHOPRIM, AND CHLORAMPHENICOL ASSOCIATED WITH ALTERATIONS IN OUTER-MEMBRANE PROTEINS OF KLEBSIELLA, ENTEROBACTER, AND SERRATIA [J].

GUTMANN, L ;

WILLIAMSON, R ;

MOREAU, N ;

KITZIS, MD ;

COLLATZ, E ;

ACAR, JF ;

GOLDSTEIN, FW .

JOURNAL OF INFECTIOUS DISEASES, 1985, 151 (03) :501-507

[4] Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli [J].

Heisig, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (04) :879-885

[5] DIFFERENCES IN SUSCEPTIBILITY TO QUINOLONES OF OUTER-MEMBRANE MUTANTS OF SALMONELLA-TYPHIMURIUM AND ESCHERICHIA-COLI [J].

HIRAI, K ;

AOYAMA, H ;

IRIKURA, T ;

IYOBE, S ;

MITSUHASHI, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 29 (03) :535-538

[6] ISOLATION AND CHARACTERIZATION OF NORFLOXACIN-RESISTANT MUTANTS OF ESCHERICHIA-COLI K-12 [J].

HIRAI, K ;

AOYAMA, H ;

SUZUE, S ;

IRIKURA, T ;

IYOBE, S ;

MITSUHASHI, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (02) :248-253

[7]

HIRAI K, 1989, INT TELESYMPOSIUM QU, P187

[8]

HIRAI K, 1990, 30 INT C ANT AG CHEM, P151

[9] APPLICATION OF TYPING BY PULSED-FIELD GEL-ELECTROPHORESIS TO THE STUDY OF CLOSTRIDIUM-DIFFICILE IN A NEONATAL INTENSIVE-CARE UNIT [J].

KATO, H ;

KATO, N ;

WATANABE, K ;

UENO, K ;

USHIJIMA, H ;

HASHIRA, S ;

ABE, T .

JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (09) :2067-2070

[10] TOPOISOMERASE-IV IS A TARGET OF QUINOLONES IN ESCHERICHIA-COLI [J].

KHODURSKY, AB ;

ZECHIEDRICH, EL ;

COZZARELLI, NR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11801-11805