Effects of repetitive transcranial magnetic stimulation in depression:: a magnetoencephalographic study

被引：11

作者：

Maihöfner, C

Ropohl, A

Reulbach, U

Hiller, M

Elstner, S

Kornhuber, J

Sperling, W

机构：

[1] Univ Erlangen Nurnberg, Dept Neurol, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Dept Psychiat & Psychol, D-91054 Erlangen, Germany

[3] Univ Erlangen Nurnberg, Inst Expt Physiol & Pathophysiol, D-91054 Erlangen, Germany

来源：

NEUROREPORT | 2005年 / 16卷 / 16期

关键词：

depression; functional imaging; magnetoencephalography; repetitive transcranial magnetic stimulation; therapy;

D O I：

10.1097/01.wnr.0000183903.77654.64

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Recently, repetitive transcranial magnetic stimulation has evolved as a potential therapeutic tool to interfere with brain changes associated with neurological and psychiatric diseases. Little is known about its mode of action, however. Here, we investigated effects of repetitive transcranial magnetic stimulation on spontaneous magnetoencephalographic activity in patients with major depression. Before treatment, depressed patients showed a significant increase in slow magnetoencephalographic activity (2-6 Hz) over the left prefrontal cortex, compared with healthy controls. This activity significantly decreased during 10 days of repetitive transcranial magnetic stimulation, paralleled by clinical improvement. We conclude that therapeutic repetitive transcranial magnetic stimulation effects can be mirrored by changes of spontaneous magnetoencephalographic activity.

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收藏

页码：1839 / 1842

页数：4

相关论文

共 19 条

[1]

AN INVENTORY FOR MEASURING DEPRESSION [J].

BECK, AT ;

ERBAUGH, J ;

WARD, CH ;

MOCK, J ;

MENDELSOHN, M .

ARCHIVES OF GENERAL PSYCHIATRY, 1961, 4 (06) :561-&

[2]

REGIONAL CEREBRAL BLOOD-FLOW IN DEPRESSION MEASURED BY POSITRON EMISSION TOMOGRAPHY - THE RELATIONSHIP WITH CLINICAL DIMENSIONS [J].

BENCH, CJ ;

FRISTON, KJ ;

BROWN, RG ;

FRACKOWIAK, RSJ ;

DOLAN, RJ .

PSYCHOLOGICAL MEDICINE, 1993, 23 (03) :579-590

[3]

A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression [J].

Berman, RM ;

Narasimhan, M ;

Sanacora, G ;

Miano, AP ;

Hoffman, RE ;

Hu, XS ;

Charney, DS ;

Boutros, NN .

BIOLOGICAL PSYCHIATRY, 2000, 47 (04) :332-337

[4]

Brain metabolic changes associated with symptom factor improvement in major depressive disorder [J].

Brody, AL ;

Saxena, S ;

Mandelkern, MA ;

Fairbanks, LA ;

Ho, ML ;

Baxter, LR .

BIOLOGICAL PSYCHIATRY, 2001, 50 (03) :171-178

[5]

A RATING SCALE FOR DEPRESSION [J].

HAMILTON, M .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (01) :56-62

[6]

Functional and metabolic analysis of cerebral ischemia using magnetoencephalography and proton magnetic resonance spectroscopy [J].

Kamada, K ;

Saguer, M ;

Moller, M ;

Wicklow, K ;

Katenhauser, M ;

Kober, H ;

Vieth, J .

ANNALS OF NEUROLOGY, 1997, 42 (04) :554-563

[7]

Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism [J].

Kimbrell, TA ;

Little, JT ;

Dunn, RT ;

Frye, MA ;

Greenberg, BD ;

Wassermann, EM ;

Repella, JD ;

Danielson, AL ;

Willis, MW ;

Benson, BE ;

Speer, AM ;

Osuch, E ;

George, MS ;

Post, RM .

BIOLOGICAL PSYCHIATRY, 1999, 46 (12) :1603-1613

[8]

The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology [J].

Kringelbach, ML ;

Rolls, ET .

PROGRESS IN NEUROBIOLOGY, 2004, 72 (05) :341-372

[9]

Cortical reorganization during recovery from complex regional pain syndrome [J].

Maihöfner, C ;

Handwerker, HO ;

Neundörfer, B ;

Birklein, F .

NEUROLOGY, 2004, 63 (04) :693-701

[10]

Cortical processing of brush-evoked allodynia [J].

Maihöfner, C ;

Neundörfer, B ;

Stefan, H ;

Handwerker, HO .

NEUROREPORT, 2003, 14 (06) :785-789