TLR5-Deficient Mice Lack Basal Inflammatory and Metabolic Defects but Exhibit Impaired CD4 T Cell Responses to a Flagellated Pathogen

被引：57

作者：

Letran, Shirdi E. ^{[1
,2
]}

Lee, Seung-Joo ^{[1
,2
]}

Atif, Shaikh M. ^{[1
,2
]}

Flores-Langarica, Adriana ^{[3
,4
]}

Uematsu, Satoshi ^{[5
,6
]}

Akira, Shizuo ^{[5
,6
]}

Cunningham, Adam F. ^{[3
,4
]}

McSorley, Stephen J. ^{[1
,2
]}

机构：

[1] Univ Minnesota, Sch Med, Ctr Infect Dis & Microbiol Translat Res, McGuire Translat Res Facil, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Div Gastroenterol Hepatol & Nutr, Dept Med,McGuire Translat Res Facil, Minneapolis, MN 55455 USA

[3] Univ Birmingham, MRC, Ctr Immune Regulat, Birmingham B1552TT, W Midlands, England

[4] Univ Birmingham, Div Immun & Infect, Birmingham B1552TT, W Midlands, England

[5] Osaka Univ, Host Def Lab, World Premier Int Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan

[6] Osaka Univ, Dept Host Def, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF IMMUNOLOGY | 2011年 / 186卷 / 09期

基金：

英国生物技术与生命科学研究理事会; 美国国家卫生研究院;

关键词：

TOLL-LIKE RECEPTORS; INNATE IMMUNITY; SALMONELLA FLAGELLIN; DENDRITIC CELLS; BACTERIAL FLAGELLIN; ADAPTIVE IMMUNITY; CROHNS-DISEASE; IN-VIVO; INFECTION; RECOGNITION;

D O I：

10.4049/jimmunol.1003576

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

TLR5-deficient mice have been reported to develop spontaneous intestinal inflammation and metabolic abnormalities. However, we report that TLR5-deficient mice from two different animal colonies display no evidence of basal inflammatory disease, metabolic abnormalities, or enhanced resistance to Salmonella infection. In contrast, the absence of TLR5 hindered the initial activation and clonal expansion of intestinal flagellin-specific CD4 T cells following oral Salmonella infection. Together, these data demonstrate that a basal inflammatory phenotype is not a consistent feature of TLR5-deficient mice and document a novel role for TLR5 in the rapid targeting of flagellin by intestinal pathogen-specific CD4 T cells. The Journal of Immunology, 2011, 186: 5406-5412.

引用

页码：5406 / 5412

页数：7

共 39 条

[1] Cutting edge:: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection [J].