Expression of Irx6 during mouse morphogenesis

被引：30

作者：

Mummenhoff, J

Houweling, AC

Peters, T

Christoffels, VM

Rüther, U ^{[1
]}

机构：

[1] Univ Dusseldorf, Inst Entwicklungs & Mol Biol Tiere, D-40225 Dusseldorf, Germany

[2] Univ Amsterdam, Acad Med Ctr, Expt & Mol Cardiol Grp, NL-1105 AZ Amsterdam, Netherlands

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 103卷 / 1-2期

关键词：

limb development; heart; neural tube; eye; mammary glands; Iroquois;

D O I：

10.1016/S0925-4773(01)00353-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Iroquois (Irx) proteins comprise a family of homeodomain-containing transcription factors involved in patterning and regionalization of embryonic tissues in both vertebrates and invertebrates. The six murine Irx genes are organized in two clusters. each consisting of three genes. Irx1, Irx2 and Irx4 belong to the IrxA cluster on chromosome 13, whereas Irx3. Irx5 and Irx6, comprising the IrxB cluster, are located on chromosome 8 (Peters et al., Genome Res. 10(2000) 1453). Developmental expression patterns have so far only been reported for five Irx genes. Here, we investigated the expression pattern of Irx6 during mouse morphogenesis and early organogenesis. The pattern was found to be much more restricted compared to the other five Irx genes, and its level of expression was much lower. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：193 / 195

页数：3

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