Monolithic silica sorbents for the separation of diastereomers by means of simulated moving bed chromatography

Monolithic silica sorbents with a dual pore system can be used in preparative chromatography for the separation of diastereomers. They exhibit some special features, which allows them to be operated at high linear velocities due to their reduced pressure drop and fast diffusion kinetics. Especially in the continuous set-up of simulated moving bed chromatography monolithic sorbents show high productivities, which make them well suited in pharmaceutical drug development for the production of pure isomers. (C) 2001 Elsevier Science B.V. All rights reserved.