Thioester-containing proteins and insect immunity

被引：169

作者：

Blandin, S

Levashina, EA

机构：

[1] European Mol Biol Lab, D-69117 Heidelberg, Germany

[2] CNRS, UPR 9022, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France

来源：

MOLECULAR IMMUNOLOGY | 2004年 / 40卷 / 12期

关键词：

thioester-containing proteins; complement factors; alpha2-macroglobulin; innate immunity; Anopheles gambiae; Drosophila melanogaster;

D O I：

10.1016/j.molimm.2003.10.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here, we discuss the role of thioester-containing proteins in innate immune responses of insects. TEPs are represented by multi-member families both in the fruitfly, Drosophila melanogaster, and in the mosquito, Anopheles gambiae. Phylogenetic analysis of the family suggests that in these two dipteran species evolution of TEPs followed independent scenarios as a result of specific adaptation to distinct ecological environments. Research on these two relatively simple model systems, which lack adaptive immunity, may provide new insights into the evolutionary origins and functions of this important protein family. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：903 / 908

页数：6

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