Neonatal lupus syndromes

被引:76
作者
Tseng, CE
Buyon, JP
机构
[1] HOSP JOINT DIS & MED CTR, DEPT RHEUMATOL, NEW YORK, NY 10003 USA
[2] NYU, SCH MED, DEPT MED, DIV RHEUMATOL, NEW YORK, NY USA
关键词
D O I
10.1016/S0889-857X(05)70313-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Congenital heart block is considered to be a model of passively acquired autoimmunity, whereby immune abnormalities in the mother lead to the production of autoantibodies that cross the placenta and presumably injure the otherwise normally developing fetus. The major targets of the maternal immune response are the SSA/Ro and SSB/La ribonucleoproteins. Other neonatal abnormalities affecting the skin, Liver, and blood elements have also been reported to be associated with anti-SSA/Ro-SSB/La antibodies in the maternal and fetal circulation and are now grouped along with congenital heart block under the heading of the neonatal lupus syndromes. This review covers the histopathology, SSA/Ro-SSB/La antigen-antibody systems, immunogenetics, clinical manifestations, and diagnosis and management strategies of these syndromes.
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页码:31 / +
页数:1
相关论文
共 122 条
[1]  
AlarconSegovia D, 1996, IMMUNOL TODAY, V17, P163
[2]   ANTI-RO SS-A ANTIBODIES IN THE PATHOPHYSIOLOGY OF CONGENITAL HEART-BLOCK IN NEONATAL LUPUS SYNDROME, AN EXPERIMENTAL-MODEL - INVITRO ELECTROPHYSIOLOGIC AND IMMUNOCYTOCHEMICAL STUDIES [J].
ALEXANDER, E ;
BUYON, JP ;
PROVOST, TT ;
GUARNIERI, T .
ARTHRITIS AND RHEUMATISM, 1992, 35 (02) :176-189
[3]   CONGENITAL HEART-BLOCK IMMUNOGENETICS - EVIDENCE OF AN ADDITIONAL ROLE OF HLA CLASS-III ANTIGENS AND INDEPENDENCE OF RO AUTOANTIBODIES [J].
ARNAIZVILLENA, A ;
VAZQUEZRODRIGUEZ, JJ ;
VICARIO, JL ;
LAVILLA, P ;
PASCUAL, D ;
MORENO, F ;
MARTINEZLASO, J .
ARTHRITIS AND RHEUMATISM, 1989, 32 (11) :1421-1426
[4]  
Aylward RD, 1928, BRIT MED J, V1928, P943
[5]  
BABOONIAN C, 1989, CLIN EXP IMMUNOL, V78, P454
[6]  
BALLARD LL, 1988, J IMMUNOL, V141, P3923
[7]   SUBACUTE CUTANEOUS LUPUS-ERYTHEMATOSUS AND DISCOID LUPUS-ERYTHEMATOSUS - COMPARATIVE HISTOPATHOLOGIC FINDINGS [J].
BANGERT, JL ;
FREEMAN, RG ;
SONTHEIMER, RD ;
GILLIAM, JN .
ARCHIVES OF DERMATOLOGY, 1984, 120 (03) :332-337
[8]   SUCCESSFUL PREGNANCY FOLLOWING STEROID-THERAPY AND PLASMA-EXCHANGE IN A WOMAN WITH ANTI-RO (SS-A) ANTIBODIES - CASE-REPORT [J].
BARCLAY, CS ;
FRENCH, MAH ;
ROSS, LD ;
SOKOL, RJ .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1987, 94 (04) :369-371
[9]   DISSOCIATION OF IMMUNE-RESPONSES TO THE SS-A (RO) 52-KD AND 60-KD POLYPEPTIDES IN SYSTEMIC LUPUS-ERYTHEMATOSUS AND SJOGRENS-SYNDROME [J].
BENCHETRIT, E ;
FOX, RI ;
TAN, EM .
ARTHRITIS AND RHEUMATISM, 1990, 33 (03) :349-355
[10]   ISOLATION AND CHARACTERIZATION OF A CDNA CLONE ENCODING THE 60-KD COMPONENT OF THE HUMAN SS-A/RO RIBONUCLEOPROTEIN AUTO-ANTIGEN [J].
BENCHETRIT, E ;
GANDY, BJ ;
TAN, EM ;
SULLIVAN, KF .
JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (04) :1284-1292