Dysregulation of melanocyte function by Th17-related cytokines: significance of Th17 cell infiltration in autoimmune vitiligo vulgaris

被引：193

作者：

Kotobuki, Yorihisa ^{[1
]}

Tanemura, Atsushi ^{[1
]}

Yang, Lingli ^{[1
]}

Itoi, Saori ^{[1
]}

Wataya-Kaneda, Mari ^{[1
]}

Murota, Hiroyuki ^{[1
]}

Fujimoto, Minoru

Serada, Satoshi

Naka, Tetsuji

Katayama, Ichiro ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Dermatol Integrated Med, Osaka, Japan

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2012年 / 25卷 / 02期

关键词：

vitiligo; Th17; cell; Th17-related cytokines; melanocyte; interaction with skin-resident cells; HIGH-FREQUENCY; T-LYMPHOCYTES; MELANOGENESIS; PATHOGENESIS; EXPRESSION; TYROSINASE; DYSFUNCTION; EPIDERMIS; ANTIBODY; DISEASE;

D O I：

10.1111/j.1755-148X.2011.00945.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The aim of this study was to determine whether CD4+IL-17A+Th17 cells infiltrate vitiligo skin and to investigate whether the proinflammatory cytokines related to Th17 cell influence melanocyte enzymatic activity and cell fate. An immunohistochemical analysis showed Th17 cell infiltration in 21 of 23 vitiligo skin samples in addition to CD8+ cells on the reticular dermis. An in vitro analysis showed that the expression of MITF and downstream genes was downregulated in melanocytes by treatment with interleukin (IL)-17A, IL-1 beta, IL-6, and tumor necrosis factor (TNF)-a. Treatment with these cytokines also induced morphological shrinking in melanocytes, resulting in decreased melanin production. In terms of local cytokine network in the skin, IL-17A dramatically induced IL-1 beta, IL-6, and TNF-a production in skin-resident cells such as keratinocytes and fibroblasts. Our results provide evidence of the influence of a complex Th17 cell-related cytokine environment in local depigmentation in addition to CD8+ cell-mediated melanocyte destruction in autoimmune vitiligo.

引用

页码：219 / 230

页数：13

共 41 条

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CORRELATION BETWEEN THE NUMBER OF MELANOSOMES, TYROSINASE MESSENGER-RNA LEVELS, AND TYROSINASE ACTIVITY IN CULTURED MURINE MELANOMA-CELLS IN RESPONSE TO VARIOUS MELANOGENESIS REGULATORY AGENTS [J].