Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1

被引：143

作者：

Aharoni, R ^{[1
]}

Teitelbaum, D ^{[1
]}

Sela, M ^{[1
]}

Arnon, R ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1998年 / 91卷 / 1-2期

关键词：

experimental autoimmune encephalomyelitis (EAE); multiple sclerosis (MS); Copaxone((R)); bystander suppression; Th2; cytokines; regulatory T cells;

D O I：

10.1016/S0165-5728(98)00166-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The synthetic amino acid copolymer, copolymer 1 (Cop 1) induces T suppressor (Ts) lines/clones, which are confined to the Th2 pathway, cross react with myelin basic protein (MBP), but not with other myelin antigens on the level of Th2 cytokine secretion. Nevertheless, Cop 1 Ts cells inhibited the IL-2 response of a proteolipid protein (PLP) specific line. Furthermore, Cop 1 Ts cells ameliorated EAE induced by two unrelated encephalitogenic epitopes of PLP: p139-151 and p178-191, that produced different forms of disease. This bystander suppression demonstrated by the Cop 1 Ts cells may explain the therapeutic effect of Cop 1 in EAE and MS. (C) 1998 Elsevier Science B.V. All rights reserved.

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页码：135 / 146

页数：12

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