Multiple sclerosis and the CTLA4 autoimmunity polymorphism CT60:: no association in patients from Germany, Hungary and Poland

被引：19

作者：

Greve, Bernhard ^{[1
]}

Simonenko, Rostislav ^{[1
]}

Illes, Zsolt ^{[2
]}

Peterfalvi, Agnes ^{[2
,3
]}

Hamdi, Nada ^{[1
]}

Mycko, Marcin P. ^{[3
]}

Selmaj, Krzysztof W. ^{[3
]}

Rozsa, Csilla

Rajczy, Katalin ^{[4
]}

Bauer, Peter ^{[5
]}

Bergerand, Klaus ^{[6
]}

Weissert, Robert ^{[1
]}

机构：

[1] Hertie Inst Clin Brain Res, Dept Gen Neurol, D-72076 Tubingen, Germany

[2] Univ Pecs, Dept Neurol, Pecs, Hungary

[3] Med Univ Lodz, Dept Neurol, Lab Neuroimmunol, Lodz, Poland

[4] Jahn Ferenc Teaching Hosp, Dept Immunogenet, Budapest, Hungary

[5] Univ Tubingen, Inst Anthropol & Human Genet, D-72074 Tubingen, Germany

[6] Univ Munster, Inst Epidemiol & Social Med, D-4400 Munster, Germany

来源：

MULTIPLE SCLEROSIS JOURNAL | 2008年 / 14卷 / 02期

关键词：

association; CTLA-4; genetics; multiple sclerosis; polymorphism;

D O I：

10.1177/1352458507082357

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Polymorphisms in the CTLA4 gene region have been associated with susceptibility to autoimmune diseases. The recently described single nucleotide polymorphism CT60, located in the 3' untranslated region of CTLA4 is associated with Graves' disease, thyroiditis, autoimmune diabetes and other autoimmune diseases. A case- control association study was conducted in German, Hungarian and Polish multiple sclerosis ( MS) patients and regional control individuals for the CTLA4 CT60 and + 49A/ G polymorphisms. No significant association of these polymorphisms or respective haplotypes with MS was found. No association of CT60 genotypes with T cell expression of ICOS and CTLA- 4 after in vitro stimulation was detected. Multiple Sclerosis 2008.

引用

页码：153 / 158

页数：6

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