Discovery of an imidazopyridine-containing 1,4-benzodiazepine nonpeptide vitronectin receptor (αvβ3) antagonist with efficacy in a restenosis model

被引：23

作者：

Keenan, RM ^{[1
]}

Lago, MA ^{[1
]}

Miller, WH ^{[1
]}

Ali, FE ^{[1
]}

Cousins, RD ^{[1
]}

Hall, LB ^{[1
]}

Hwang, SM ^{[1
]}

Jakas, DR ^{[1
]}

Kwon, C ^{[1
]}

Louden, C ^{[1
]}

Nguyen, TT ^{[1
]}

Ohlstein, EH ^{[1
]}

Rieman, DJ ^{[1
]}

Ross, ST ^{[1
]}

Samanen, JM ^{[1
]}

Smith, BR ^{[1
]}

Stadel, J ^{[1
]}

Takata, DT ^{[1
]}

Vickery, L ^{[1
]}

Yuan, CCK ^{[1
]}

Yue, TL ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Div Res & Dev, Collegeville, PA 19426 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(98)00556-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the 3-oxo-1,4-benzodiazepine-2-acetic acid series of vitronectin receptor (alpha v beta 3) antagonists, a compound containing an imidazopyridine arginine mimetic was discovered which had sufficient potency and iv pharmacokinetics for demonstration of efficacy in a rat restenosis model. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3171 / 3176

页数：6

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