Effect of immunostimulatory CpG-oligonucleotides in chronic lymphocytic leukemia B cells

被引：20

作者：

Decker, T ^{[1
]}

Peschel, C ^{[1
]}

机构：

[1] Tech Univ Munich, Dept Med 3, D-81675 Munich, Germany

来源：

LEUKEMIA & LYMPHOMA | 2001年 / 42卷 / 03期

关键词：

immunostimulation; CpG oligonucleotides; B-CLL cells;

D O I：

10.3109/10428190109064586

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bacterial DNA and phosphothioate oligonucleotides containing a CpG motif (CpG-ODN) can activate cells of the immune system such as monocytes, dendritic cells and B cells. Protective immune responses against pathogens and tumor cells were observed in murine models when mice were treated with CpG-ODN. Recent results have demonstrated strong activation of human immune cells as well. Apart from stimulating cells of the immune system, CpG ODN have many direct effects on B-CLL cells such as upregulation of costimulatory molecules, cell cycle entry and upregulation of potential target antigens for antibody therapy. Therefore, CpG-ODN appear to be attractive compounds to be included into new therapeutic strategies like tumor cell vaccination and adoptive T cell transfer or therapy with monoclonal antibodies. In this review, the effects of CpG-ODN on B-CLL cells are summarized and potential therapeutic applications of CpG-ODN in chronic lymphocytic leukemia are discussed.

引用

页码：301 / 307

页数：7

共 78 条

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