Drosophila heartless acts with Heartbroken/Dof in muscle founder differentiation

被引：39

作者：

Dutta, D ^{[1
]}

Shaw, S ^{[1
]}

Maqbool, T ^{[1
]}

Pandya, H ^{[1
]}

VijayRaghavan, K ^{[1
]}

机构：

[1] Tata Inst Fundamental Res, Natl Ctr Biol Sci, Bangalore, Karnataka, India

来源：

PLOS BIOLOGY | 2005年 / 3卷 / 10期

关键词：

D O I：

10.1371/journal.pbio.0030337

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The formation of a multi-nucleate myofibre is directed, in Drosophila, by a founder cell. In the embryo, founders are selected by Notch-mediated lateral inhibition, while during adult myogenesis this mechanism of selection does not appear to operate. We show, in the muscles of the adult abdomen, that the Fibroblast growth factor pathway mediates founder cell choice in a novel manner. We suggest that the developmental patterns of Heartbroken/Dof and Sprouty result in defining the domain and timing of activation of the Fibroblast growth factor receptor Heartless in specific myoblasts, thereby converting them into founder cells. Our results point to a way in which muscle differentiation could be initiated and define a critical developmental function for Heartbroken/Dof in myogenesis.

引用

页码：1789 / 1800

页数：12

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