Neutrophil homeostasis - A new role for stromal cell-derived factor-1

被引:38
作者
Link, DC [1 ]
机构
[1] Washington Univ, Sch Med, Div Oncol, Dept Med, St Louis, MO 63110 USA
关键词
neutrophils; stromal cell-derived factor-1; granulocyte colony-stimulating factor; CXCR4; leukocyte trafficking;
D O I
10.1385/IR:32:1-3:169
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Neutrophils are a key component of the innate immune response and a major contributor to inflammation. Accordingly, their number in the blood is tightly controlled. Neutrophils are normally produced exclusively in the bone marrow, and their release into the blood is tightly regulated to maintain homeostatic levels in the blood. Herein, recent evidence is reviewed showing that stromal cell-derived factor- 1 (SDF- 1, CXCL 12) plays a key role in regulating neutrophil trafficking in the bone marrow. Moreover, studies are discussed showing that granulocyte colony-stimulating factor, primarily through regulation of SDF-1 expression in the bone marrow, plays an essential role in maintaining neutrophil homeostasis in the blood.
引用
收藏
页码:169 / 178
页数:10
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