Effects of adolescent nicotine exposure on opioid consumption and neuroendocrine responses in adult male and female rats

被引：42

作者：

Klein, LC ^{[1
]}

机构：

[1] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA

来源：

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY | 2001年 / 9卷 / 03期

关键词：

D O I：

10.1037//1064-1297.9.3.251

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Effects of adolescent nicotine exposure on illicit drug consumption and neuroendocrine functioning were examined in adult rats. Nicotine (NIC; 2 doses) or saline (SAL) was administered via osmotic minipumps to 30 male and 30 female adolescent Wistar rats for 19 days. After NIC/SAL cessation, oral opioid consumption was assessed in the home cage for 4 weeks. Plasma corticosterone and ACTH were measured at the end of the experiment. Low-NIC male rats consumed more fentanyl than did high-NIC male rats; opioid consumption among adult female rats was not altered by NIC exposure. Females consumed more fentanyl than did males, regardless of NIC history. NIC exposure increased adult corticosterone and ACTH levels in a dose-dependent manner. Results suggest important effects of adolescent NIC exposure, including altered neuroendocrine status and opioid consumption.

引用

页码：251 / 261

页数：11

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