Paclitaxel-initiated, controlled polymerization of lactide for the formulation of polymeric nanoparticulate delivery vehicles

被引：161

作者：

Tong, Rong ^{[1
]}

Cheng, Jianjun ^{[1
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 26期

基金：

美国国家科学基金会;

关键词：

drug delivery; nanoparticles; nanotechnology; polymer-drug conjugates; ring-opening polymerization;

D O I：

10.1002/anie.200800491

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Paclitaxel-polylactide nanoconjugates were prepared by the site-specific polymerization of lactide mediated by a paclitaxel-metal complex followed by nanoprecipitation (see scheme). The resulting nanoconjugates have nearly 100% paclitaxel incorporation efficiencies and predefined drug loadings, and are less than 100 nm in diameter. The drug burst release effect is completely eliminated with this drug delivery vehicle. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4830 / 4834

页数：5

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