Invasion of the leukocytes into the fetal-maternal interface during pregnancy

被引：160

作者：

Gomez-Lopez, Nardhy ^{[1
,2
,3
,5
]}

Guilbert, Larry J. ^{[4
]}

Olson, David M. ^{[2
,3
]}

机构：

[1] Univ Alberta, Heritage Med Res Ctr 227, Preterm Birth & Healthy Outcomes Team, Dept Obstet & Gynecol, Edmonton, AB T6G 2S2, Canada

[2] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2S2, Canada

[3] Univ Alberta, Dept Physiol, Edmonton, AB T6G 2S2, Canada

[4] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2S2, Canada

[5] Res Direct, Inst Nacl Perinatol Isidro Espinosa Reyes, Mexico City, DF, Mexico

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2010年 / 88卷 / 04期

关键词：

NATURAL-KILLER-CELLS; DELTA-T-CELLS; UTERINE MAST-CELLS; DECIDUAL NK CELLS; NONPREGNANT HUMAN-ENDOMETRIUM; EXTRA-PLACENTAL MEMBRANES; HUMAN TERM PREGNANCY; PRETERM LABOR; MOUSE UTERUS; HUMAN PARTURITION;

D O I：

10.1189/jlb.1209796

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

No other organ in the body undergoes such an invasion of selective cells (leukocytes) and release of homing molecules, CAMs, proinflammatory cytokines, and mediators or undergoes similar extensive remodeling of tissues over such a short period of time as the pregnant uterus. This is especially interesting, as an infectious process involving microorganisms does not exist in a healthy pregnancy and delivery. Furthermore, after delivery of the baby and placenta, the uterus involutes and returns to its normal monthly cycling, and most of the leukocytes are swept away or leave. In this review, we discuss leukocyte infiltration and recruitment and the potential roles of each subpopulation of leukocytes in relation to pregnancy and the problems of preterm birth, pre-eclampsia, and intrauterine growth restriction. J. Leukoc. Biol. 88: 625-633; 2010.

引用

页码：625 / 633

页数：9

共 121 条

[1]

Immune phenotype and cytotoxic activity of lymphocytes from human term decidua against trophoblast [J].