Aspects of β-amyloid as a biomarker for Alzheimer's disease

被引：74

作者：

Andreasson, Ulf ^{[1
]}

Portelius, Erik ^{[1
]}

Andersson, Malin E. ^{[1
]}

Blennow, Kaj ^{[1
]}

Zetterberg, Henrik ^{[1
]}

机构：

[1] Univ Gothenburg, Clin Neurochem Lab, Sahlgrenska Univ Hosp, S-43180 Molndal, Sweden

来源：

BIOMARKERS IN MEDICINE | 2007年 / 1卷 / 01期

关键词：

D O I：

10.2217/17520363.1.1.59

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Alzheimer's disease is an age-related neurodegenerative disorder that results in progressive cognitive impairment and death. The accumulation of beta-amyloid A(beta) in specific brain regions is believed by many to represent the earliest event in the pathogenesis of the disease. Here, we review the key aspects of A beta as a biomarker for Alzheimer's disease, including the pathogenicity of A beta, the possible biological functions of its precursor protein, the A beta metabolism and homeostasis, the diagnostic performance of different A beta assays in different settings and the potential usefulness of A beta as a surrogate marker for treatment efficacy in clinical trials of novel A beta-targeting drugs against Alzheimer's disease.

引用

页码：59 / 78

页数：20

共 228 条

[1] The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region [J].

Acquati, F ;

Accarino, M ;

Nucci, C ;

Fumagalli, P ;

Jovine, L ;

Ottolenghi, S ;

Taramelli, R .

FEBS LETTERS, 2000, 468 (01) :59-64

[2] Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and Alzheimer disease [J].

Adair, JC ;

Charlie, J ;

Dencoff, JE ;

Kaye, JA ;

Quinn, JF ;

Camicioli, RM ;

Stetler-Stevenson, WG ;

Rosenberg, GA .

STROKE, 2004, 35 (06) :E159-E162

[3] Cerebrospinal fluid tau and Aβ42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment [J].

Andreasen, N ;

Minthon, L ;

Vanmechelen, E ;

Vanderstichele, H ;

Davidsson, P ;

Winblad, B ;

Blennow, K .

NEUROSCIENCE LETTERS, 1999, 273 (01) :5-8

[4] Cerebrospinal fluid levels of total-tau, phospho-tau and Aβ42 predicts development of Alzheimer's disease in patients with mild cognitive impairment [J].

Andreasen, N ;

Vanmechelen, E ;

Vanderstichele, H ;

Davidsson, P ;

Blennow, K .

ACTA NEUROLOGICA SCANDINAVICA, 2003, 107 :47-51

[5] The functions of mammalian amyloid precursor protein and related amyloid precursor-like proteins [J].

Anliker, Brigitte ;

Mueller, Ulrike .

NEURODEGENERATIVE DISEASES, 2006, 3 (4-5) :239-246

[6] Presenilin 1 controls γ-secretase processing of amyloid precursor protein in pre-Golgi compartments of hippocampal neurons [J].

Annaert, WG ;

Levesque, L ;

Craessaerts, K ;

Dierinck, I ;

Snellings, G ;

Westaway, D ;

George-Hyslop, PS ;

Cordell, B ;

Fraser, P ;

De Strooper, B .

JOURNAL OF CELL BIOLOGY, 1999, 147 (02) :277-294

[7] CSF phosphorylated tau protein and mild cognitive impairment: a prospective study [J].

Arai, H ;

Ishiguro, K ;

Ohno, H ;

Moriyama, M ;

Itoh, N ;

Okamura, N ;

Matsui, T ;

Morikawa, Y ;

Horikawa, E ;

Kohno, H ;

Sasaki, H ;

Imahori, K .

EXPERIMENTAL NEUROLOGY, 2000, 166 (01) :201-203

[8] ANGIOTENSIN CONVERTING ENZYME IN ALZHEIMERS-DISEASE - INCREASED ACTIVITY IN CAUDATE-NUCLEUS AND CORTICAL AREAS [J].

ARREGUI, A ;

PERRY, EK ;

ROSSOR, M ;

TOMLINSON, BE .

JOURNAL OF NEUROCHEMISTRY, 1982, 38 (05) :1490-1492

[9] CHARACTERIZATION OF NEUTRAL PROTEINASES FROM ALZHEIMER-AFFECTED AND CONTROL BRAIN SPECIMENS - IDENTIFICATION OF CALCIUM-DEPENDENT METALLOPROTEINASES FROM THE HIPPOCAMPUS [J].

BACKSTROM, JR ;

MILLER, CA ;

TOKES, ZA .

JOURNAL OF NEUROCHEMISTRY, 1992, 58 (03) :983-992

[10]

Backstrom JR, 1996, J NEUROSCI, V16, P7910

← 1 2 3 4 5 6 7 8 9 10 →