Is pancreatic core biopsy sufficient to diagnose autoimmune chronic pancreatitis?

被引：62

作者：

Bang, Sung-Jo ^{[2
]}

Kim, Myung-Hwan ^{[1
]}

Kim, Do Ha ^{[2
]}

Lee, Tae Yoon ^{[1
]}

Kwon, Seunghyun ^{[1
]}

Oh, Hyoung-Chul ^{[1
]}

Kim, Ji Young ^{[1
]}

Hwang, Chang Yun ^{[1
]}

Lee, Sang Soo ^{[1
]}

Seo, Dong Wan ^{[1
]}

Lee, Sung Koo ^{[1
]}

Song, Dong Eun ^{[3
]}

Jang, Se Jin ^{[3
]}

机构：

[1] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul 138736, South Korea

[2] Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Internal Med, Ulsan 680749, South Korea

[3] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pathol, Seoul 138736, South Korea

来源：

PANCREAS | 2008年 / 36卷 / 01期

关键词：

autoimmune chronic pancreatitis; lymphoplasmacytic; sclerosing pancreatitis; IgG4; immunostaining;

D O I：

10.1097/mpa.0b013e318135483d

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Objectives: This study aimed to evaluate the adequacy of pancreatic core biopsy in histological diagnosis of autoimmune chronic pancreatitis (AIP). Methods: Histopathologic study as well as immunohistochemical staining using anti-IgG4 antibody was done with pancreatic tissue specimens of 26 AIP patients (19 transabdominal ultrasound (US)-guided core biopsies, 3 intraoperative wedge biopsies, and 4 surgical resections). Eight patients with alcoholic chronic pancreatitis and 10 patients with pancreatic cancer served as controls. Results: Lymphoplasmacytic sclerosing pancreatitis (LPSP) histology was observed in 26% (5/19) of US-guided core biopsy specimens, 33% (1/3) of open biopsy specimens, and all 4 resection specimens in AIP patients. None of the patients in the control group showed the full spectrum of changes of LPSP. Abundant IgG4-positive cells (> 10 cells/high-power field) in the pancreas were observed in 21% (4/19) of AIP patients with US-guided core biopsy specimen. Abundant IgG4-positive cells in the pancreas were also observed in 2 of 8 patients with chronic alcoholic pancreatitis and 1 of 10 patients with pancreatic cancer. Conclusions: Transabdominal US-guided pancreatic core biopsy may not provide enough tissue to evaluate characteristic histopathologic features of AIP that include LPSP or abundant IgG4-positive cell infiltration. The LPSP histology may be specific to AIP, but abundant IgG4-positive cells in the pancreas may not.

引用

页码：84 / 89

页数：6

共 44 条

[1]

[Anonymous], 2002, SUIZO

[2]

Antibodies to carbonic anhydrase and IgG4 levels in idiopathic chronic pancreatitis: relevance for diagnosis of autoimmune pancreatitis [J].