Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

被引：414

作者：

Huang, ZL

Qu, WM

Eguchi, N

Chen, JF

Schwarzschild, MA

Fredholm, BB

Urade, Y

Hayaishi, O ^{[1
]}

机构：

[1] Osaka Biosci Inst, Dept Mol Behav Biol, Osaka 5650874, Japan

[2] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[3] Massachusetts Gen Hosp, Mol Neurobiol Lab, Boston, MA 02129 USA

[4] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 07期

基金：

日本学术振兴会;

关键词：

D O I：

10.1038/nn1491

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Caffeine, a component of tea, coffee and cola, induces wakefulness. It binds to adenosine A(1) and A(2A) receptors as an antagonist, but the receptor subtype mediating caffeine-induced wakefulness remains unclear. Here we report that caffeine at 5, 10 and 15 mg kg(-1) increased wakefulness in both wild-type mice and A(1) receptor knockout mice, but not in A(2A) receptor knockout mice. Thus, caffeine-induced wakefulness depends on adenosine A(2A) receptors.

引用

页码：858 / 859

页数：2

共 15 条

[1] Adenosine and sleep-wake regulation [J].