Direct Patterning of protein- and cell-resistant polymeric monolayers and microstructures

被引：109

作者：

Khademhosseini, A

Jon, S

Suh, KY

Tran, TNT

Eng, G

Yeh, J

Seong, J

Langer, R

机构：

[1] MIT, Dept Biol Engn, Cambridge, MA 02142 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02142 USA

[3] Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

ADVANCED MATERIALS | 2003年 / 15卷 / 23期

关键词：

SELF-ASSEMBLED MONOLAYERS; POLY(ETHYLENE GLYCOL); MAMMALIAN-CELLS; SURFACES; FABRICATION; COCULTURES; HEPATOCYTES; ATTACHMENT; SYSTEMS; FILMS;

D O I：

10.1002/adma.200305433

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel method of patterning cells and proteins with a copolymer comprised of poly-anchoring groups is presented. As such, the technique allows for control over surface topography and surface molecules. The potential use of the technique for the development of improved biosensors and analytical tools is an area of active research.

引用

收藏

页码：1995 / 2000

页数：6

相关论文

共 30 条

[11]

2-H

[12] Microstamping on an activated polymer surface: Patterning biotin and streptavidin onto common polymeric biomaterials [J].

Hyun, J ;

Zhu, YJ ;

Liebmann-Vinson, A ;

Beebe, TP ;

Chilkoti, A .

LANGMUIR, 2001, 17 (20) :6358-6367

[13] Universal route to cell micropatterning using an amphiphilic comb polymer [J].

Hyun, JH ;

Ma, HW ;

Zhang, ZP ;

Beebe, TP ;

Chilkoti, A .

ADVANCED MATERIALS, 2003, 15 (7-8) :576-579

[14]

JON S, 2003, IN PRESS LANGMUIR

[15] Fabrication of three-dimensional microstructures by soft molding [J].

Kim, YS ;

Suh, KY ;

Lee, HH .

APPLIED PHYSICS LETTERS, 2001, 79 (14) :2285-2287

[16] Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold [J].

Mrksich, M ;

Chen, CS ;

Xia, YN ;

Dike, LE ;

Ingber, DE ;

Whitesides, GM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (20) :10775-10778

[17] Using microcontact printing to pattern the attachment of mammalian cells to self-assembled monolayers of alkanethiolates on transparent films of gold and silver [J].

Mrksich, M ;

Dike, LE ;

Tien, J ;

Ingber, DE ;

Whitesides, GM .

EXPERIMENTAL CELL RESEARCH, 1997, 235 (02) :305-313

[18] Using self-assembled monolayers to understand the interactions of man-made surfaces with proteins and cells [J].

Mrksich, M ;

Whitesides, GM .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 1996, 25 :55-78

[19]

ONEILL C, 1990, J CELL SCI, V95, P577

[20] Patterning mammalian cells using elastomeric membranes [J].

Ostuni, E ;

Kane, R ;

Chen, CS ;

Ingber, DE ;

Whitesides, GM .

LANGMUIR, 2000, 16 (20) :7811-7819