The synthesis and chelation chemistry of DOTA-peptide conjugates

被引：214

作者：

De Leon-Rodriguez, Luis M. ^{[1
]}

Kovacs, Zoltan ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Adv Imaging Res Ctr, Dallas, TX 75390 USA

来源：

BIOCONJUGATE CHEMISTRY | 2008年 / 19卷 / 02期

关键词：

D O I：

10.1021/bc700328s

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metal complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid)-peptide conjugates are increasingly used as targeted imaging and therapeutic radiopharmaceuticals and MRI contrast agents. This review covers the bifunctional derivatives of DOTA, the solution and solid-phase synthesis of DOTA-peptide conjugates, their coordination and chelation chemistry, and the biomedical applications of various DOTA-peptide conjugate metal complexes.

引用

页码：391 / 402

页数：12

共 131 条

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