Transgenic models for exploring gonadotropin biology in the male

被引：7

作者：

Allan, CM ^{[1
]}

Handelsman, DJ ^{[1
]}

机构：

[1] Univ Sydney, ANZAC Res Inst, Sydney, NSW 2139, Australia

来源：

ENDOCRINE | 2005年 / 26卷 / 03期

关键词：

transgenic; FSH; LH; mouse; testis; male;

D O I：

10.1385/ENDO:26:3:235

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Unraveling the selective actions of the two pituitary-derived gonadotropins FSH and LH in vivo is complicated by their very close structural and functional similarities, and their coordinate regulation. Both gonadotrophins are composed of a common a-subunit and distinct beta-subunits, which are simultaneously secreted as heterodimers in response to a single trophic hormone GnRH. Functionally, gonadotrophins interact with related receptors and share the same ultimate cellular site in the testis, the Sertoli cell with receptors for both FSH and the androgens synthesized in response to LH. This article will review the strategies to overcome these intimate connections and discuss key findings from transgenic models developed to study gonadotropin actions in the male.

引用

页码：235 / 239

页数：5

共 46 条

[1]

The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction [J].

Abel, MH ;

Wootton, AN ;

Wilkins, V ;

Huhtaniemi, I ;

Knight, PG ;

Charlton, HM .

ENDOCRINOLOGY, 2000, 141 (05) :1795-1803

[2]

Complete sertoli cell proliferation induced by follicle-stimulating hormone (FSH) independently of luteinizing hormone activity: Evidence from genetic models of isolated FSH action [J].

Allan, CM ;

Garcia, A ;

Spaliviero, J ;

Zhang, FP ;

Jimenez, M ;

Huhtaniemi, I ;

Handelsman, DJ .

ENDOCRINOLOGY, 2004, 145 (04) :1587-1593

[3]

A novel transgenic model to characterize the specific effects of follicle-stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions [J].

Allan, CM ;

Haywood, M ;

Swaraj, S ;

Spaliviero, J ;

Koch, A ;

Jimenez, M ;

Poutanen, M ;

Levallet, J ;

Huhtaniemi, I ;

Illingworth, P ;

Handelsman, DJ .

ENDOCRINOLOGY, 2001, 142 (06) :2213-2220

[4]

IMMUNOHISTOCHEMICAL LOCALIZATION OF ANDROGEN RECEPTORS IN THE RAT TESTIS - EVIDENCE FOR STAGE-DEPENDENT EXPRESSION AND REGULATION BY ANDROGENS [J].

BREMNER, WJ ;

MILLAR, MR ;

SHARPE, RM ;

SAUNDERS, PTK .

ENDOCRINOLOGY, 1994, 135 (03) :1227-1234

[5]

THE EFFECTS OF DAILY ADMINISTRATION OF SINGLE AND MULTIPLE INJECTIONS OF GONADOTROPIN-RELEASING HORMONE ON PITUITARY AND GONADAL-FUNCTION IN THE HYPOGONADAL (HPG) MOUSE [J].

CHARLTON, HM ;

HALPIN, DMG ;

IDDON, C ;

ROSIE, R ;

LEVY, G ;

MCDOWELL, IFW ;

MEGSON, A ;

MORRIS, JF ;

BRAMWELL, A ;

SPEIGHT, A ;

WARD, BJ ;

BROADHEAD, J ;

SMITH, GD ;

FINK, G .

ENDOCRINOLOGY, 1983, 113 (02) :535-544

[6]

CHATTANACH BM, 1977, NATURE, V269, P338

[7]

Prediction of severity of symptoms in iatrogenic ovarian hHyperstimulation syndrome by follicle-stimulating hormone receptor Ser680 Asn polymorphism [J].

Daelemans, C ;

Smits, G ;

de Maertelaer, V ;

Costagliola, S ;

Englert, Y ;

Vassart, G ;

Delbaere, A .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (12) :6310-6315

[8]

Impairing follicle-stimulating hormone (FSH) signaling in vivo:: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance [J].

Dierich, A ;

Sairam, MR ;

Monaco, L ;

Fimia, GM ;

Gansmuller, A ;

LeMeur, M ;

Sassone-Corsi, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) :13612-13617

[9]

An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man [J].

Gromoll, J ;

Simoni, M ;

Nieschlag, E .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (04) :1367-1370

[10]

Spermatogenesis without gonadotropins: Maintenance has a lower testosterone threshold than initiation [J].

Handelsman, DJ ;

Spaliviero, JA ;

Simpson, JM ;

Allan, CM ;

Singh, J .

ENDOCRINOLOGY, 1999, 140 (09) :3938-3946

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