Kinetic and spectroscopic characterization of an intermediate peroxynitrite complex in the nitrogen monoxide induced oxidation of oxyhemoglobin (vol 439, pg 85, 1998)

被引：71

作者：

Herold, S ^{[1
]}

机构：

[1] ETH Zurich, Anorgan Chem Lab, CH-8092 Zurich, Switzerland

来源：

FEBS LETTERS | 1999年 / 443卷 / 01期

关键词：

D O I：

10.1016/S0014-5793(98)01591-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Stopped-flow spectroscopy studies of the nitrogen monoxide mediated oxidation of oxyhemoglobin in the pH range 5-10.5 show that an intermediate can be characterized at alkaline pH. The rate of decay of this species to methemoglobin increases significantly with decreasing pH such that it does not accumulate in quantities large enough to be observed under neutral or acidic conditions. Kinetic and spectroscopic properties of this intermediate support its assignment as a methemoglobin peroxynitrite complex. (C) 1999 Federation of European Biochemical Societies.

引用

页码：80 / 84

页数：5

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