Immunostimulating activity of the polysaccharides isolated from Cordyceps militaris

被引：188

作者：

Lee, Jong Seok ^{[1
]}

Hong, Eock Kee ^{[1
]}

机构：

[1] Kangwon Natl Univ, Dept Bioengn & Technol, Coll Engn, Chunchon 200701, Gangwondo, South Korea

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2011年 / 11卷 / 09期

关键词：

Cordyceps militaris; Immunostimulating activity; NF-kappa B; MAPKs; Pattern-recognition receptors; MACROPHAGE ACTIVATION; BETA-GLUCANS; STRUCTURAL CHARACTERISTICS; PURIFIED POLYSACCHARIDES; HERICIUM-ERINACEUS; IMMUNE RECOGNITION; MURINE MACROPHAGES; CYTO-TOXICITY; FRUITING BODY; RECEPTOR;

D O I：

10.1016/j.intimp.2011.04.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

In this study, the signaling mechanism of the polysaccharides isolated from fruiting body of Cordyceps militaris (CM) was investigated in macrophages to evaluate its immuno-stimulating properties. We found that CM was capable of upregulation of NO, ROS, TNF-alpha and phagocytic uptake in mouse peritoneal macrophages and RAW264.7 macrophages. Macrophages activation by CM seemed to occur via activation of NF-kappa B and all three MAPKs pathways through dectin-1 and TLR2 macrophage receptors. Additionally, we showed that CM suppressed in vivo growth of melanoma in an experimental mouse model. Based on these data, we suggested that CM may potentially regulate the immune response. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1226 / 1233

页数：8

共 40 条

[1]

Polysaccharides isolated from Phellinus gilvus inhibit melanoma growth in mice [J].