Incidence of pancreatitis in patients undergoing sphincter of oddi manometry (SOM)

被引:73
作者
Maldonado, ME [1 ]
Brady, PG [1 ]
Mamel, JJ [1 ]
Robinson, B [1 ]
机构
[1] Univ S Florida, Coll Med, Dept Internal Med, Tampa, FL 33612 USA
关键词
D O I
10.1016/S0002-9270(98)00745-X
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objective: Sphincter of Oddi manometry (SOM) is a useful diagnostic procedure when evaluating patients with unexplained biliary pain or idiopathic recurrent pancreatitis. Acute pancreatitis is a recognized complication of SOM hose pathogenesis appears to be multifactoral. We conducted this study to determine the incidence of pancreatitis in patients after SOM and to identify any variables that may lead to an increased incidence of pancreatitis. Methods: A retrospective review of 100 consecutive patients who underwent SOM between 1992 and 1996 at two university-affiliated hospitals was done. SOM was performed using a triple lumen catheter with each lumen perfused at a rate of 0.25 cc/min using an Arndorfer pneumohydraulic capillary perfusion system. The following data were recorded: age, gender, clinical type of sphincter of Oddi dysfunction, length of procedure, doses of medications used, duct cannulated, sphincter of Oddi pressure, whether endoscopic retrograde cholangiopancreatography (ERCP) with or without sphincterotomy was performed, and the number of patients developing pancreatitis. Statistical analysis was performed using a T test chi(2), and multiple regression analysis. Results: The overall incidence of pancreatitis was 17%. Six patients with type II SO dysfunction and 11 patients with type III SO dysfunction developed pancreatitis. The incidence of pancreatitis was significantly lower in those patients who only had SOM, compared with those patients who had SOM and ERCP (9.3% vs 26.1%,p < 0.026). There was no significant correlation between age, gender, duration of procedure, dose of midazolam used, sphincter of Oddi pressure, or type of SO dysfunction with the development of SOM-induced pancreatitis. Multiple regression analysis showed that sphincterotomy added no additional risk, beyond that associated with ERCP, for the development of pancreatitis. Conclusions: The results of this study indicate that the incidence of pancreatitis was highest when SOM was followed by ERCP. A potential method of decreasing the incidence of pancreatitis after SOM is performing ERCP with or without sphincterotomy at another session, separated from the SOM by at least 24 h. Before this can be definitely recommended, the results of this study must be validated by others or by a prospective study. (Am J Gastroenterol 1999;94: 387-390. (C) 1999 by Am. Cell. of Gastroenterology).
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页码:387 / 390
页数:4
相关论文
共 22 条
  • [1] SEVERE ACUTE-PANCREATITIS COMPLICATING SPHINCTER OF ODDI MANOMETRY
    ALBERT, MB
    STEINBERG, WM
    IRANI, SK
    [J]. GASTROINTESTINAL ENDOSCOPY, 1988, 34 (04) : 342 - 345
  • [2] CATTAU E, 1988, GASTROINTEST ENDOSC, V34, P185
  • [3] Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography
    Cavallini, G
    Tittobello, A
    Frulloni, L
    Masci, E
    Mariani, A
    DiFrancesco, V
    Angelini, GP
    Casarini, MB
    Bedogni, G
    Conigliaro, R
    Bonardi, L
    Khajekini, MTA
    Cipolletta, L
    Bianco, MA
    Costamagna, G
    Perri, V
    Dobrilla, G
    DePretis, G
    Familiari, L
    Giacobbe, G
    Fratton, A
    Carone, N
    Loriga, P
    Muscas, A
    Mazzeo, F
    Gaeta, L
    Miglioli, M
    Pezzilli, R
    Morelli, A
    Santucci, L
    Naccarato, R
    DelFavero, G
    Orlandi, F
    Macarri, GP
    Russo, A
    Virgilio, C
    Uomo, G
    Manes, G
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (13) : 919 - 923
  • [4] ENDOSCOPIC SPHINCTEROTOMY COMPLICATIONS AND THEIR MANAGEMENT - AN ATTEMPT AT CONSENSUS
    COTTON, PB
    LEHMAN, G
    VENNES, J
    GEENEN, JE
    RUSSELL, RCG
    MEYERS, WC
    LIGUORY, C
    NICKL, N
    [J]. GASTROINTESTINAL ENDOSCOPY, 1991, 37 (03) : 383 - 393
  • [5] Complications of endoscopic biliary sphincterotomy
    Freeman, ML
    Nelson, DB
    Sherman, S
    Haber, GB
    Herman, ME
    Dorsher, PJ
    Moore, JP
    Fennerty, MB
    Ryan, ME
    Shaw, MJ
    Lande, JD
    Pheley, AM
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (13) : 909 - 918
  • [6] GEENEN JE, 1980, GASTROENTEROLOGY, V78, P317
  • [7] THE EFFICACY OF ENDOSCOPIC SPHINCTEROTOMY AFTER CHOLECYSTECTOMY IN PATIENTS WITH SPHINCTER-OF-ODDI DYSFUNCTION
    GEENEN, JE
    HOGAN, WJ
    DODDS, WJ
    TOOULI, J
    VENU, RP
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (02) : 82 - 87
  • [8] ACUTE-PANCREATITIS FOLLOWING ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY
    HAMILTON, I
    LINTOTT, DJ
    ROTHWELL, J
    AXON, ATR
    [J]. CLINICAL RADIOLOGY, 1983, 34 (05) : 543 - 546
  • [9] Hogan WJ, 1997, GASTROINTEST ENDOSC, V45, P342
  • [10] KING CE, 1988, GASTROENTEROLOGY, V94, pA227