Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium

被引:110
作者
Kuhara, T [1 ]
Iigo, M
Itoh, T
Ushida, Y
Sekine, K
Terada, N
Okamura, H
Tsuda, H
机构
[1] Natl Inst Canc Res, Expt Pathol & Chemotherapy Div, Tokyo, Japan
[2] Morinaga Milk Ind Co Ltd, Biochem Res Lab, Kanagawa, Japan
[3] Hyogo Med Univ, Inst Adv Med Sci, Nishinomiya, Hyogo, Japan
[4] Hyogo Med Univ, Dept Pathol, Nishinomiya, Hyogo, Japan
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2000年 / 38卷 / 02期
关键词
D O I
10.1207/S15327914NC382_8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The effects of oral administration of bovine lactoferrin (bLF) and its hydrolysate on the lung colonization by colon 26 carcinoma were investigated. At doses of 100 or 300 mg/kg/day for seven successive days, bLFs demonstrated a significant inhibitory effect on experimental metastasis, which indicated effectiveness before and after tumor implantation. Oral administration of bLFs augmented CD4(+), CD8(+), and asialoGM1(+) cells in the spleen and peripheral blood. Their cytotoxic activities against Yac-1 and colon 26 carcinoma were enhanced by HE In the small intestinal epithelium, CD4(+) and CD8(+) cells were markedly increased, and, simultaneously, enhanced production of interleukin-18 (IL-18) was confirmed in the intestinal epithelial cells. In this model, intravenous injection of marine IL-18 showed significant inhibition of the lung colonization by colon 26 carcinoma. These results suggested that inhibition of experimental metastasis by oral administration of bLF and pepsin hydrolysate of bLF might be due to enhanced cellular immunity; presumably mediated by enhanced IL-18 production in the intestinal epithelium.
引用
收藏
页码:192 / 199
页数:8
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