Amoebapores

被引：124

作者：

Leippe, M

机构：

[1] Department of Molecular Biology, Bernhard Nocht Inst. for Trop. Med., 20359 Hamburg

来源：

PARASITOLOGY TODAY | 1997年 / 13卷 / 05期

关键词：

D O I：

10.1016/S0169-4758(97)01038-7

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The enormous cytolytic potential of Entamoeba histolytica appeals to parasitologists and immunologists because it kills target cells in a contact-dependent reaction resembling that of cytotoxic lymphocytes. In this review, Matthias Leippe summarizes what is currently known about a family of pore-forming peptides termed 'amoebapores', to which the cytolytic effect has been attributed, and describes the structural and functional properties of these potent factors, as well as their structure-activity relationships. Finally, a comparison is made with effector molecules of the mammalian defensive system.

引用

收藏

页码：178 / 183

页数：6

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