Influenza B virus encephalitis

被引:69
作者
McCullers, JA
Facchini, S
Chesney, PJ
Webster, RG
机构
[1] St Jude Childrens Res Hosp, Dept Virol & Mol Biol, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA
[3] Univ Tennessee, Dept Pathol, Memphis, TN USA
[4] Univ Tennessee, Lebonheur Childrens Med Ctr, Dept Pediat, Div Infect Dis, Memphis, TN USA
[5] Univ Tennessee, Lebonheur Childrens Med Ctr, Dept Pediat, Div Pediat Neurol, Memphis, TN USA
关键词
D O I
10.1086/515214
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Acute encephalitis and postinfectious encephalopathy have been reported infrequently in association with influenza A and B virus infections, We report herein a case of a 6-year-old girl with acute influenza B virus encephalitis resulting in neurological sequelae. The diagnosis was made by isolation of influenza B virus from the nasopharynx seroconversion to influenza B, and reverse transcription polymerase chain reaction (RT-PCR) identification of the virus from the patient's cerebrospinal fluid. Direct sequencing of viral RNA from the patient's nasopharynx and cerebrospinal fluid revealed identical nucleotide sequences in the HA1 region of the hemagglutinin gene. This is the first report of influenza B virus encephalitis diagnosed by use of RT-PCR and illustrates the need for increased awareness of influenza virus as a cause of acute encephalitis. PCR may be a useful tool for diagnosing future cases.
引用
收藏
页码:898 / 900
页数:3
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