Protein homeostasis and aging: Role of ubiquitin protein ligases

被引：63

作者：

Jana, Nihar Ranjan ^{[1
]}

机构：

[1] Natl Brain Res Ctr, Cellular & Mol Neurosci Lab, Manesar 122050, Gurgaon, India

来源：

NEUROCHEMISTRY INTERNATIONAL | 2012年 / 60卷 / 05期

关键词：

Ubiquitin; Proteasome; Aging; Ubiquitin ligase; Oxidative stress; Protein homeostasis; GENE-EXPRESSION PROFILE; PROTEASOME SYSTEM; OXIDATIVE STRESS; C.-ELEGANS; POLYGLUTAMINE PROTEINS; CAENORHABDITIS-ELEGANS; DEGRADATION; LONGEVITY; AGGREGATION; INHIBITION;

D O I：

10.1016/j.neuint.2012.02.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Protein homeostasis is fundamental in normal cellular function and cell survival. The ubiquitin-proteasome system (UPS) plays a central role in maintaining the protein homeostasis network through selective elimination of misfolded and damaged proteins. Impaired function of UPS is implicated in normal aging process and also in several age-related neurodegenerative disorders that are characterized by increased accumulation oxidatively modified proteins and protein aggregates. Growing literature also indicate the potential role of various ubiquitin protein ligases in the regulation of aging process by enhancing the degradation of either central lifespan regulators or abnormally folded and damaged proteins. This review mainly focuses on our current understanding of the importance of UPS function in the regulation of normal aging process. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：443 / 447

页数：5

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