Receptor-mediated clearance of Cryptococcus neoformans capsular polysaccharide in vivo

被引：30

作者：

Yauch, LE

Mansour, MK

Levitz, SM

机构：

[1] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 12期

关键词：

D O I：

10.1128/IAI.73.12.8429-8432.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cryptococcus neoformans capsular glucuronoxylomannan (GXM) is shed during cryptococcosis and taken up by macrophages. The roles of the putative GXM receptors CD14, CD18, Toll-like receptor 2 (TLR2), and TLR4 in GXM clearance from serum and deposition in the liver and spleen in receptor-deficient mice were studied. While alterations in the kinetics of GXM redistribution were seen in the mutant mice, none of the receptors was absolutely required for serum clearance or hepatosplenic accumulation.

引用

收藏

页码：8429 / 8432

页数：4

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