Classifying organic crystals via in-process image analysis and the use of monitoring charts to follow polymorphic and morphological changes

被引：97

作者：

De Anda, JC ^{[1
]}

Wang, XZ ^{[1
]}

Lai, X ^{[1
]}

Roberts, KJ ^{[1
]}

机构：

[1] Univ Leeds, Dept Chem Engn, Inst Particle Sci & Engn, Leeds LS2 9JT, W Yorkshire, England

来源：

JOURNAL OF PROCESS CONTROL | 2005年 / 15卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

on-line imaging; image analysis; process monitoring; crystallisation; crystal shape; crystal polymorphs; crystal morphology; crystal habit; (L)-glutamic acid;

D O I：

10.1016/j.jprocont.2005.02.002

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

The polymorphic and morphological forms, and growth rates of different crystal facets are important parameters in pharmaceutical crystallisation processes that call for techniques for their real-time monitoring. In this paper, we describe a method for real-time classification of crystal polymorphic and morphological forms based on on-line imaging and image analysis. The focus of discussion is on deriving quantitative shape descriptors from images obtained on-line in real-time, automatic classification of crystals, the estimation of ratios of different polymorphs and new monitoring charts showing the relative average growth rates of facets of crystals. The work presented is based on experimental results of crystallisation in a batch reactor of (L)-glutamic acid that has two polymorphs, the prismatic alpha and needle-shaped beta forms. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：785 / 797

页数：13

共 51 条

[1] Affine-similar shape retrieval: Application to multiview 3-D object recognition [J].

Abbasi, S ;

Mokhtarian, F .

IEEE TRANSACTIONS ON IMAGE PROCESSING, 2001, 10 (01) :131-139

[2]

Barrett P, 2003, CHEM ENG PROG, V99, P26

[3] Characterizing the metastable zone width and solubility curve using lasentec FBRM and PVM [J].

Barrett, P ;

Glennon, B .

CHEMICAL ENGINEERING RESEARCH & DESIGN, 2002, 80 (A7) :799-805

[4] Classification of crystal shape using Fourier descriptors and mathematical morphology [J].

BernardMichel, B ;

Rohani, S ;

Pons, MN ;

Vivier, H ;

Hundal, HS .

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 1997, 14 (04) :193-200

[5]

CANNY J, 1986, IEEE T PATTERN ANAL, V36, P961

[6] ART-2 - SELF-ORGANIZATION OF STABLE CATEGORY RECOGNITION CODES FOR ANALOG INPUT PATTERNS [J].

CARPENTER, GA ;

GROSSBERG, S .

APPLIED OPTICS, 1987, 26 (23) :4919-4930

[7] Application of wavelets and neural networks to diagnostic system development, 1, feature extraction [J].

Chen, BH ;

Wang, XZ ;

Yang, SH ;

McGreavy, C .

COMPUTERS & CHEMICAL ENGINEERING, 1999, 23 (07) :899-906

[8] Invariant Fourier-wavelet descriptor for pattern recognition [J].

Chen, GY ;

Bui, TD .

PATTERN RECOGNITION, 1999, 32 (07) :1083-1088

[9] A wavelet method for analysis of droplet and particle images for monitoring heterogeneous processes [J].

Chen, J ;

Wang, XZ .

CHEMICAL ENGINEERING COMMUNICATIONS, 2005, 192 (04) :499-515

[10] HABIT95 - A program for predicting the morphology of molecular crystals as a function of the growth environment [J].

Clydesdale, G ;

Roberts, KJ ;

Docherty, R .

JOURNAL OF CRYSTAL GROWTH, 1996, 166 (1-4) :78-83

← 1 2 3 4 5 6 →