Evidence for a role of endogenous cannabinoids in the modulation of acute and tonic pain sensitivity

被引：88

作者：

Strangman, NM

Patrick, SL

Hohmann, AG

Tsou, K

Walker, JM

机构：

[1] Brown Univ, Dept Psychol, Schrier Res Lab, Providence, RI 02912 USA

[2] Brown Univ, Dept Neurosci, Providence, RI 02912 USA

来源：

BRAIN RESEARCH | 1998年 / 813卷 / 02期

关键词：

formalin; pain; hyperalgesia; cannabinoid; SR141716A;

D O I：

10.1016/S0006-8993(98)01031-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The competitive CB1 receptor antagonist SR141716A was used to test the hypothesis that endogenous cannabinoids modulate tonic pain sensitivity. Pretreatment with the antagonist significantly enhanced the response to a chemical nociceptive stimulus in the formalin test. Postreatment with the antagonist 5 min following the induction of tonic pain produced hyperalgesia during the tonic phase only. These findings suggest that endogenous cannabinoids serve naturally to modulate the maintenance of pain following repeated noxious stimulation. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：323 / 328

页数：6

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