A prospective longitudinal study of BK virus infection in 104 renal transplant recipients

被引:184
作者
Bressollette-Bodin, C
Coste-Burel, M
Hourmant, M
Sebille, V
Andre-Garnier, E
Imbert-Marcille, BM [1 ]
机构
[1] Univ Hosp Nantes, Virol Lab, Nantes, France
[2] Univ Nantes, Dept Stat, F-44035 Nantes, France
[3] Univ Hosp Nantes, Dept Nephrol & Clin Immunol, Nantes, France
[4] Univ Hosp Nantes, Clin Res Unit, Nantes, France
关键词
BK virus; genetic variability; plasma; renal transplantation; urine; viral load;
D O I
10.1111/j.1600-6143.2005.00934.x
中图分类号
R61 [外科手术学];
学科分类号
摘要
BK virus (BKV) infection during the first year after renal transplantation was studied prospectively in 104 unselected consecutive patients. Viral DNA in urine (DNAuria) and plasma (DNAemia) samples was detected and quantified by real-time PCR. The noncoding control region (NCCR) of BKV isolates was sequenced. DNAuria and DNAemia occurred in 57% and 29% of patients, respectively. Three groups were defined, uninfected patients (group 1, n = 45), patients with DNAuria (group 2, n = 29) and patients with positive DNAemia (group 3, n = 30). Active infection started within the first 3 months in 80% of patients. Cold ischemia duration over 24 h and the administration of tacrolimus were identified as significant risks factors for DNAuria, whereas it remains more frequently negative in patients receiving cyclosporine A. The risk for positive DNAemia was higher in patients with DNAuria (notably for viral load (VL) > 4 log/mL) or treated with tacrolimus. No relationship was found with genetic variability in the NCCR sequence. Our data highlight the high frequency of active BKV infection after renal transplantation. Although high VL was detected in some patients, none developed a BKV nephropathy. A prospective follow-up of the whole population during the first year post renal transplantation is thus not useful to predict BKV disease.
引用
收藏
页码:1926 / 1933
页数:8
相关论文
共 44 条
  • [1] HLA mismatching increases the risk of BK virus nephropathy in renal transplant recipients
    Awadalla, Y
    Randhawa, P
    Ruppert, K
    Zeevi, A
    Duquesnoy, RJ
    [J]. AMERICAN JOURNAL OF TRANSPLANTATION, 2004, 4 (10) : 1691 - 1696
  • [2] Human polyomaviruses DNA detection in peripheral blood leukocytes from immunocompetent and immunocompromised individuals
    Azzi, A
    DeSantis, R
    Ciappi, S
    Leoncini, F
    Sterrantino, G
    Marino, N
    Mazzotta, F
    Laszlo, D
    Fanci, R
    Bosi, A
    [J]. JOURNAL OF NEUROVIROLOGY, 1996, 2 (06) : 411 - 416
  • [3] Polyoma viral infection in renal transplantation: the role of immunosuppressive therapy
    Barri, YM
    Ahmad, I
    Ketel, BL
    Barone, GW
    Walker, PD
    Bonsib, SM
    Abul-Ezz, SR
    [J]. CLINICAL TRANSPLANTATION, 2001, 15 (04) : 240 - 246
  • [4] High reactivation of BK virus variants in Asian Indians with renal disorders and during pregnancy
    Bhattacharjee, S
    Chakraborty, T
    [J]. VIRUS GENES, 2004, 28 (02) : 157 - 168
  • [5] Rapid quantification and differentiation of human polyomavirus DNA in undiluted urine from patients after bone marrow transplantation
    Biel, SS
    Held, TK
    Landt, O
    Niedrig, M
    Gelderblom, HR
    Siegert, W
    Nitsche, P
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (10) : 3689 - 3695
  • [6] Polyomavirus disease under new immunosuppressive drugs - A cause of renal graft dysfunction and graft loss
    Binet, I
    Nickeleit, V
    Hirsch, HH
    Prince, O
    Dalquen, P
    Gudat, F
    Mihatsch, MJ
    Thiel, G
    [J]. TRANSPLANTATION, 1999, 67 (06) : 918 - 922
  • [7] Chatterjee M, 2000, J MED VIROL, V60, P353, DOI 10.1002/(SICI)1096-9071(200003)60:3&lt
  • [8] 353::AID-JMV16&gt
  • [9] 3.0.CO
  • [10] 2-R