Organic anion transport is the primary function of the SLC17/type I phosphate transporter family

被引:136
作者
Reimer, RJ [1 ]
Edwards, RH
机构
[1] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA
[2] Univ Calif San Francisco, Dept Neurol, Grad Program Neurosci, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Dept Physiol, Grad Program Neurosci, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Dept Physiol, Grad Program Cell Biol, San Francisco, CA 94143 USA
[5] Univ Calif San Francisco, Dept Neurol, Grad Program Cell Biol, San Francisco, CA 94143 USA
来源
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2004年 / 447卷 / 05期
关键词
neurotransmitter transporter; organic anion transport; sialin; type I phosphate transporter; vesicular glutamate transporter;
D O I
10.1007/s00424-003-1087-y
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Recently, molecular studies have determined that the SLC17/type I phosphate transporters, a family of proteins initially characterized as phosphate carriers, mediate the transport of organic anions. While their role in phosphate transport remains uncertain, it is now clear that the transport of organic anions facilitated by this family of proteins is involved in diverse processes ranging from the vesicular storage of the neurotransmitter glutamate to the degradation and metabolism of glycoproteins.
引用
收藏
页码:629 / 635
页数:7
相关论文
共 50 条
  • [1] Molecular cloning of a novel brain-type Na+-dependent inorganic phosphate cotransporter
    Aihara, Y
    Mashima, H
    Onda, H
    Hisano, S
    Kasuya, H
    Hori, T
    Yamada, S
    Tomura, H
    Yamada, Y
    Inoue, I
    Kojima, I
    Takeda, J
    [J]. JOURNAL OF NEUROCHEMISTRY, 2000, 74 (06) : 2622 - 2625
  • [2] BASIC LOCAL ALIGNMENT SEARCH TOOL
    ALTSCHUL, SF
    GISH, W
    MILLER, W
    MYERS, EW
    LIPMAN, DJ
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) : 403 - 410
  • [3] The spectrum of SLC17A5-gene mutations resulting in free sialic acid-storage diseases indicates some genotype-phenotype correlation
    Aula, N
    Salomäki, P
    Timonen, R
    Verheijen, F
    Mancini, G
    Månsson, JE
    Aula, P
    Peltonen, L
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2000, 67 (04) : 832 - 840
  • [4] Unraveling the molecular pathogenesis of free sialic acid storage disorders: altered targeting of mutant sialin
    Aula, N
    Jalanko, A
    Aula, P
    Peltonen, L
    [J]. MOLECULAR GENETICS AND METABOLISM, 2002, 77 (1-2) : 99 - 107
  • [5] AULA P, 2001, METABOLIC MOL BASES, P5109
  • [6] Characterization of vesicular glutamate transporter in pancreatic α- and β-cells and its regulation by glucose
    Bai, LQ
    Zhang, XH
    Ghishan, FK
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2003, 284 (05): : G808 - G814
  • [7] Molecular and functional analysis of a novel neuronal vesicular glutamate transporter
    Bai, LQ
    Xu, H
    Collins, JF
    Ghishan, FK
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (39) : 36764 - 36769
  • [8] Bellocchio EE, 1998, J NEUROSCI, V18, P8648
  • [9] Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter
    Bellocchio, EE
    Reimer, RJ
    Fremeau, RT
    Edwards, RH
    [J]. SCIENCE, 2000, 289 (5481) : 957 - 960
  • [10] LOCALIZATION OF NAPI-1, A NA/PI COTRANSPORTER, IN RABBIT KIDNEY PROXIMAL TUBULES .2. LOCALIZATION BY IMMUNOHISTOCHEMISTRY
    BIBER, J
    CUSTER, M
    WERNER, A
    KAISSLING, B
    MURER, H
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1993, 424 (3-4): : 210 - 215