Plasmacytoid monocytes/T cells: a dendritic cell lineage?

被引:46
作者
Galibert, L
Maliszewski, CR
Vandenabeele, S
机构
[1] Immunex Corp, Discovery Res, Seattle, WA 98101 USA
[2] PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Melbourne, Vic 3050, Australia
[3] Cooperat Res Ctr Vaccine Technol, Brisbane, Qld, Australia
关键词
plasmacytoid T-cells; plasmacytoid monocytes; dendritic cells; type I interferon;
D O I
10.1006/smim.2001.0324
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Plasmacytoid monocytes/T cells were first described in 1958, yet their origin and function have remained enigmatic. Recently a series of publications brought these cells to the forefront of immunological research. Indeed, plasmacytoid monocytes/T-cells contain natural type-I interferon producing cells and can differentiate in vitro into dendritic cells (DC). It has been proposed that plasmacytoid monocytes/T-cells represent a distinct lineage of cells whose fate it is to differentiate into dendritic cells. Herein we will review recent advances in our understanding of plasmacytoid monocytes/T cells and highlight arguments in favor or against this lineage hypothesis. We propose that plasmacytoid monocytes/T cells represent a composite group of both myeloid and lymphoid early-committed cells that are characterized by their ability to differentiate in vitro into DC. (C) 2001 Academic Press.
引用
收藏
页码:283 / 289
页数:7
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