plasmacytoid T-cells;
plasmacytoid monocytes;
dendritic cells;
type I interferon;
D O I:
10.1006/smim.2001.0324
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Plasmacytoid monocytes/T cells were first described in 1958, yet their origin and function have remained enigmatic. Recently a series of publications brought these cells to the forefront of immunological research. Indeed, plasmacytoid monocytes/T-cells contain natural type-I interferon producing cells and can differentiate in vitro into dendritic cells (DC). It has been proposed that plasmacytoid monocytes/T-cells represent a distinct lineage of cells whose fate it is to differentiate into dendritic cells. Herein we will review recent advances in our understanding of plasmacytoid monocytes/T cells and highlight arguments in favor or against this lineage hypothesis. We propose that plasmacytoid monocytes/T cells represent a composite group of both myeloid and lymphoid early-committed cells that are characterized by their ability to differentiate in vitro into DC. (C) 2001 Academic Press.
机构:
Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USAHematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Arpinati, M
Green, CL
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Green, CL
Heimfeld, S
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Heimfeld, S
Heuser, JE
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Heuser, JE
Anasetti, C
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
机构:
Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USAHematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Arpinati, M
Green, CL
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Green, CL
Heimfeld, S
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Heimfeld, S
Heuser, JE
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
Heuser, JE
Anasetti, C
论文数: 0引用数: 0
h-index: 0
机构:Hematol Inc, Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA