Alterations in phagocyte function and periodontal infection

被引:43
作者
Daniel, MA [1 ]
VanDyke, TE [1 ]
机构
[1] BOSTON UNIV, GOLDMAN SCH GRAD DENT, DEPT PERIODONTOL & ORAL BIOL, BOSTON, MA 02118 USA
关键词
periodontitis; juvenile pathology; neutrophils; T cells; superantigens; monocytes;
D O I
10.1902/jop.1996.67.10s.1070
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
A REVIEW OF PHAGOCYTIC CELLS-polymorphonuclear leukocytes and monocytes-in the inflammatory process is presented. Examples of phagocyte defect-related pathology serve as a framework for understanding the role of these cells in periodontal infection. The role of alterations in neutrophil function in localized juvenile periodontitis is presented as a model system for understanding periodontal pathology as a result of host-related functional abnormalities. Two topical alternative hypotheses for periodontal breakdown are presented in which macrophage control of the chronic lesion is altered by an absence of T cells or the influence of bacterial superantigens.
引用
收藏
页码:1070 / 1075
页数:6
相关论文
共 47 条
[1]   Altered neutrophil function in localized juvenile periodontitis: Intrinsic or induced? [J].
Agarwal, S ;
Huang, JP ;
Piesco, NP ;
Suzuki, JB ;
Riccelli, AE ;
Johns, LP .
JOURNAL OF PERIODONTOLOGY, 1996, 67 (03) :337-344
[2]   ALTERED FREE CYTOSOLIC CALCIUM CHANGES AND NEUTROPHIL CHEMOTAXIS IN PATIENTS WITH JUVENILE PERIODONTITIS [J].
AGARWAL, S ;
REYNOLDS, MA ;
DUCKETT, LD ;
SUZUKI, JB .
JOURNAL OF PERIODONTAL RESEARCH, 1989, 24 (02) :149-154
[3]   THE SEVERE AND MODERATE PHENOTYPES OF HERITABLE MAC-1, LFA-1 DEFICIENCY - THEIR QUANTITATIVE DEFINITION AND RELATION TO LEUKOCYTE DYSFUNCTION AND CLINICAL-FEATURES [J].
ANDERSON, DC ;
SCHMALSTEIG, FC ;
FINEGOLD, MJ ;
HUGHES, BJ ;
ROTHLEIN, R ;
MILLER, LJ ;
KOHL, S ;
TOSI, MF ;
JACOBS, RL ;
WALDROP, TC ;
GOLDMAN, AS ;
SHEARER, WT ;
SPRINGER, TA .
JOURNAL OF INFECTIOUS DISEASES, 1985, 152 (04) :668-689
[4]  
Babior BM, 1983, METABOLIC BASIS INHE, P1956
[5]  
BOREL JF, 1985, INT ARCH ALLER A IMM, V35, P194
[6]  
CASLEYSMITH JR, 1980, CELL BIOL INFLAMMATI, P53
[7]   DEFECTIVE POLYMORPHONUCLEAR LEUKOCYTE FUNCTION IN A HUMAN PERIODONTAL-DISEASE [J].
CIANCIOLA, LJ ;
GENCO, RJ ;
PATTERNS, MR ;
MCKENNA, J ;
VANOSS, CJ .
NATURE, 1977, 265 (5593) :445-447
[8]   DEFECTIVE NEUTROPHIL CHEMOTAXIS IN JUVENILE PERIODONTITIS [J].
CLARK, RA ;
PAGE, RC ;
WILDE, G .
INFECTION AND IMMUNITY, 1977, 18 (03) :694-700
[9]  
COATES TD, 1991, BLOOD, V78, P1338
[10]  
CORCORAN ML, 1992, J BIOL CHEM, V267, P515